Synthesis, crystal structure, and Helicobacter pylori urease inhibition of a dicyanoamide bridged Cu(I/II) complex

A dicyanoamide-bridged polymeric copper(I/II) complex, [Cu-II(sal)(bipy)Cu-I(dca)(2)](n), was prepared by reaction of 5-methylchlorosalicylaldehyde (Hsal), 2,2-bipyridine (bipy), sodium dicyanoamide (Nadca), and copper perchlorate in methanol. The complex was characterized by elemental analyses, infrared and electronic spectroscopy, and single-crystal X-ray determination. Cu-II has a square pyramidal coordination, and Cu-I has triangular coordination. The complex showed high urease inhibitory activity with IC50 value of 0.16 +/- 0.23M. [GRAPHICS] .