期刊
JOURNAL OF COORDINATION CHEMISTRY
卷 69, 期 20, 页码 2999-3009出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2016.1225198
关键词
Mixed-ligand palladium complexes; supramolecular; anticancer; oxidative stress; DNA-ladder analysis
资金
- World Academy of Sciences [11-143RG/PHA/AS_C-UNESCO FR:3240262658]
Three new heteroleptic palladium(II) dithiocarbamates with better in vitro anticancer activity than cisplatin were synthesized and characterized by different analytical techniques, elemental analysis, FTIR, NMR, and single crystal X-ray diffraction analysis. The Pd center is chelated by dithiocarbamate ligand {4-benzylpiperazine-1-carbodithioate (1) and (3) or (4-(2-methoxyphenyl)piperazine-1-carbodithioate (2)}, triorganophosphine {tris-(4-flourophenyl)-phosphine (1) and (2) or tris-(4-chlorophenyl)phosphine (3)}, and a chloro-group, resulting in a square planar geometry. The packing diagram reveals a 3D network (1 and 2) and a 2D network (3) composed of various 1D chains in which the molecules are linked via hydrogen bonds (1-3) and halide (1, 3) interactions. The anticancer activities of complexes against HeLa cell line varies in the sequence 2 (23.438M) >1 (38.293M)>3 (47.554M)>cisplatin (78.075M). The cytotoxicity of these complexes is due to their strong induction of oxidative stress and DNA-damage ability leading to apoptosis. [GRAPHICS]
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