期刊
JOURNAL OF CONTROLLED RELEASE
卷 225, 期 -, 页码 152-169出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2016.01.033
关键词
Bone regeneration; Tissue engineering; Dual drug delivery
资金
- National Science Council (NSC) of Taiwan [NSC 103-2221-E-011-032]
- Pasteur Institute of Iran
Bone formation is a complex process that requires concerted function of multiple growth factors. For this, it is essential to design a delivery system with the ability to load multiple growth factors in order to mimic the natural microenvironment for bone tissue formation. However, the short half-lives of growth factors, their relatively large size, slow tissue penetration, and high toxicity suggest that conventional routes of administration are unlikely to be effective. Therefore, it seems that using multiple bioactive factors in different delivery systems can develop new strategies for improving bone tissue regeneration. Combination of these factors along with biomaterials that permit tunable release profiles would help to achieve truly spatiotemporal regulation during delivery. This review summarizes the various dual-control release systems that are used for bone tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
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