期刊
JOURNAL OF CONTROLLED RELEASE
卷 223, 期 -, 页码 215-223出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.12.048
关键词
Metastasis; Circulating tumor cells; TRAIL; Nanomedicine
资金
- NCI NIH HHS [U54 CA143876] Funding Source: Medline
Prostate cancer, once it has progressed from its local to metastatic form, is a disease with poor prognosis and limited treatment options. Here we demonstrate an approach using nanoscale liposomes conjugated with E-selectin adhesion protein and Apo2L/TRAIL (TNF-related apoptosis-inducing ligand) apoptosis ligand that attach to the surface of leukocytes and rapidly clear viable cancer cells from circulating blood in the living mouse. For the first time, it is shown that such an approach can be used to prevent the spontaneous formation and growth of metastatic tumors in an orthotopic xenograftmodel of prostate cancer, by greatly reducing the number of circulating tumor cells. We conclude that the use of circulating leukocytes as a carrier for the anti-cancer protein TRAIL could be an effective tool to directly target circulating tumor cells for the prevention of prostate cancer metastasis, and potentially other cancers that spread through the bloodstream. (C) 2015 Elsevier B.V. All rights reserved.
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