期刊
JOURNAL OF CONTROLLED RELEASE
卷 231, 期 -, 页码 68-76出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2016.01.006
关键词
Multivalent host-guest chemistry; Paclitaxel; Cyclodextrin; SPION; Magnetic-guided drug delivery
This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, beta-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between beta-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems. (C) 2016 Elsevier B.V. All rights reserved.
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