期刊
JOURNAL OF FOOD BIOCHEMISTRY
卷 46, 期 10, 页码 -出版社
WILEY-HINDAWI
DOI: 10.1111/jfbc.14297
关键词
food allergy; intestinal barrier; intestinal microbiome; olive oil; ovalbumin
资金
- Jimei University Young Talent Program
- National Key Research and Development Program of China [2019YFC1605003-3]
- Jimei University [ZR2020001]
This study demonstrates that olive oil can alleviate food allergy symptoms by regulating intestinal microecological balance and improving intestinal lesions and immune function.
Increasing evidence indicates that intestinal microecological imbalances are strongly associated with food allergen intolerance. This study investigated the effect of olive oil on food allergy susceptibility and intestinal microecology based on an ovalbumin (OVA)-sensitized mouse model. The results indicated that the allergic symptoms of sensitized mice were alleviated when they were supplemented with olive oil at 1-3 g/kg per day for 7 weeks. Intestinal epithelium observation showed repaired ileum villi and upregulated tight junction (TJ) protein expression. Furthermore, the levels of the cytokines (e.g., IL-10) secreted by regulatory T cells were increased, whereas T helper 2 (Th2) cell-associated factors were decreased in lamina propria. Furthermore, 16S rRNA sequencing indicated reduced Burkholderiaceae and increased Clostridiaceae in the intestinal microflora. The results suggest that an olive oil-enriched diet may effectively prevent food allergies by regulating the intestinal microecological balance. Practical applications Recent studies emphasized that intestinal ecological imbalance, including intestinal immunity and microflora structure, plays an important role in affecting the occurrence and development of food allergy. The present results implied that olive oil, one of the main components of the Mediterranean diet, can effectively ameliorate the symptoms of OVA-induced food allergy by regulating intestinal microecological homeostasis. Therefore, dietary supplementation with olive oil may be an effective strategy for preventing food allergies.
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