期刊
JOURNAL OF CONTROLLED RELEASE
卷 240, 期 -, 页码 202-211出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2015.12.014
关键词
Macrophages; Targeted delivery; Intracellular drug delivery; Intracellular infection; Tumor-associated macrophages
资金
- NSF [DMR-1410987]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1410987] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1056997] Funding Source: National Science Foundation
Macrophages are prevalent in the body and have roles in almost every aspect of human biology. They have often been considered a subject to avoid during drug delivery. However, with recent understanding of their diverse functions in diseases, macrophages have gained increasing interest as important therapeutic targets. To develop drug carriers to macrophages, it is important to understand their biological roles and requirements for efficient targeting. This review provides an overview of representative carriers and various approaches to address challenges in drug delivery to macrophages such as biodistribution, cellular uptake, intracellular trafficking, and drug release. (C) 2015 Elsevier B.V. All rights reserved.
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