期刊
JOURNAL OF CONTROLLED RELEASE
卷 240, 期 -, 页码 414-433出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2016.02.033
关键词
Embolics; Polymers; Drug eluting beads; Hepatocellular carcinoma; Arteriovenous malformations; Uterine fibroids
资金
- NIH [R41 CA168123, RO1 CA107621, F30 CA176922]
- NSF [GRF 2015210207]
- University of Utah
Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation. (C) 2016 Elsevier B.V. All rights reserved.
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