期刊
JOURNAL OF CROHNS & COLITIS
卷 17, 期 1, 页码 37-48出版社
OXFORD UNIV PRESS
DOI: 10.1093/ecco-jcc/jjac091
关键词
Crohn's disease; ulcerative colitis; inflammatory bowel disease; patient experience
This study reports on the impact of the COVID-19 outbreak in patients with inflammatory bowel disease (IBD). The results show that the risk of COVID-19 and severe COVID-19 is not increased in IBD patients compared to the general population. There is also no negative impact of IBD-related medication on the risk of COVID-19 or severe COVID-19. Additionally, the COVID-19 outbreak led to a decrease in endoscopic and imaging procedures, but did not affect clinical activity and treatment.
Background and Aims There are concerns regarding the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease [IBD]. We report on the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD Patients and Methods We prospectively collected data from 5457 patients with IBD nested in the ongoing I-CARE project and still followed up in April 2020, with monthly online monitoring of clinical activity, treatment, imaging and endoscopy. Investigators were also contacted to report incidental cases. Results In total, 233 [4.3%] reported COVID-19 and 12 [0.2%] severe COVID-19, with no COVID-19 deaths. The risk of COVID-19 in patients with IBD was not increased compared to the general population (standardized incidence ratio [SIR]: 1.18, 95% confidence interval [CI] [1.03-1.34], p = 0.009), as well as the risk of severe COVID-19 (SIR: 0.69, 95% CI [0.35-1.20], p = 0.93). We did not observe any negative impact of the different IBD-related medication on the risk of either COVID-19 or severe COVID-19. In 2020, the COVID-19 outbreak resulted in a drastic decrease in endoscopic and imaging procedures from March to May 2020 compared to 2018 and 2019. No impacts on clinical IBD disease activity as well as ongoing treatment were noted. Conclusion No increases in either COVID-19 or severe COVID-19 incidences were observed in patients with IBD. There was no impact of COVID-19 on IBD-related medication and clinical activity. Access to endoscopy and imaging was restricted during the first months of the first COVID-19 outbreak.
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