4.8 Article

Real-time evaluation of a hydrogel delivery vehicle for cancer immunotherapeutics within embedded spheroid cultures

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

Hussein A. Tawbi et al.

Summary: LAG-3 and PD-1 are two distinct inhibitory immune checkpoints that contribute to T-cell exhaustion. The combination of relatlimab and nivolumab has been shown to be safe and effective in previously treated melanoma patients, and this study aimed to evaluate its safety and activity in previously untreated melanoma patients. The results demonstrated that the combination therapy provided a greater benefit in terms of progression-free survival compared to nivolumab alone, without any new safety signals.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Nanoscience & Nanotechnology

Graft-Then-Shrink: Simultaneous Generation of Antifouling Polymeric Interfaces and Localized Surface Plasmon Resonance Biosensors

Alexander H. Jesmer et al.

Summary: The article introduces a material prepared using graft-then-shrink method, which exhibits improved antifouling surface properties and intrinsic localized surface plasmon resonance (LSPR) sensor capabilities. This method successfully enhances polymer packing and generates wrinkled gold structures for LSPR biosensing. Compared to traditional methods, this technique effectively reduces biofouling and improves the sensitivity of the sensors.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Multidisciplinary Sciences

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Giulia Agliardi et al.

Summary: Research shows that local delivery of IL-12 combined with CAR-T cell therapy can achieve durable anti-tumor responses by enhancing cytotoxicity of CAR-T cells, reshaping the tumor microenvironment, promoting immune cell infiltration, and activating the myeloid compartment.

NATURE COMMUNICATIONS (2021)

Article Immunology

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

Siqi Guo et al.

Summary: The study demonstrates that IL-15/IL-15R alpha complex enhances CD8 T cell expansion and has potential efficacy in inhibiting breast cancer growth and improving cytotoxicity. Further research is needed to optimize the effectiveness of IL-15cx as an immunotherapy for breast cancer.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Julien Edeline et al.

Summary: CAR-T cells and BiTE immunotherapies have shown remarkable efficacy in treating B cell hematologic malignancies, but their application in solid tumors is challenging with early clinical trial results falling short of expectations. However, various strategies for improvement are currently being explored.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Cell & Tissue Engineering

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

Parvez Vora et al.

CELL STEM CELL (2020)

Article Biotechnology & Applied Microbiology

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

Bryan D. Choi et al.

NATURE BIOTECHNOLOGY (2019)

Article Nanoscience & Nanotechnology

Displacement Affinity Release of Antibodies from Injectable Hydrogels

Vincent Huynh et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Biochemistry & Molecular Biology

Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery

Vincent Huynh et al.

CHEMBIOCHEM (2019)

Article Chemistry, Multidisciplinary

Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels

Muhammad M. Shoaib et al.

RSC ADVANCES (2019)

Review Pharmacology & Pharmacy

Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction

Wei Chen et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels

Vincent Huynh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biotechnology & Applied Microbiology

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Li Tang et al.

NATURE BIOTECHNOLOGY (2018)

Article Engineering, Biomedical

Delivery Strategies for Immune Checkpoint Blockade

Qian Chen et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Review Multidisciplinary Sciences

Hydrogel microenvironments for cancer spheroid growth and drug screening

Yunfeng Li et al.

SCIENCE ADVANCES (2018)

Review Chemistry, Multidisciplinary

Recent progress in enzymatic protein labelling techniques and their applications

Yi Zhang et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Multidisciplinary Sciences

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent

Alice O. Kamphorst et al.

SCIENCE (2017)

Article Materials Science, Biomaterials

Embedded Spheroids as Models of the Cancer Microenvironment

Kristie M. Tevis et al.

ADVANCED BIOSYSTEMS (2017)

Review Multidisciplinary Sciences

Designer protein delivery: From natural to engineered affinity-controlled release systems

Malgosia M. Pakulska et al.

SCIENCE (2016)

Review Pharmacology & Pharmacy

Blinatumomab: A First-in-Class Bispecific T-Cell Engager for Precursor B-Cell Acute Lymphoblastic Leukemia

Larry W. Buie et al.

ANNALS OF PHARMACOTHERAPY (2015)

Article Cell & Tissue Engineering

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in Three-Dimensional Culture

Marisol Herrera-Perez et al.

TISSUE ENGINEERING PART A (2015)

Review Cell Biology

Bispecific T-cell engagers for cancer immunotherapy

Amelia M. Huehls et al.

IMMUNOLOGY AND CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Affinity-Based Drug Delivery Systems for Tissue Repair and Regeneration

Katarina Vulic et al.

BIOMACROMOLECULES (2014)

Article Chemistry, Multidisciplinary

Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation

Emma M. Pelegri-O'Day et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates

Daniel V. Santi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Immunology

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Kaori Sakuishi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

Site-specific protein modification on living cells catalyzed by Sortase

Tsutomu Tanaka et al.

CHEMBIOCHEM (2008)

Article Multidisciplinary Sciences

Identification of human brain tumour initiating cells

SK Singh et al.

NATURE (2004)

Article Multidisciplinary Sciences

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells

KB Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)