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Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance

期刊

JOURNAL OF CONTROLLED RELEASE
卷 347, 期 -, 页码 175-182

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ELSEVIER
DOI: 10.1016/j.jconrel.2022.05.004

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Nanogel; Cancer vaccine; Lymph node delivery; Tumor-associated macrophages; Tumor immune resistance

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This article introduces a new cancer vaccine that uses self-assembled nanogels as an antigen delivery system for cancer immunotherapy. It also proposes a novel technology that utilizes nanogels to regulate tumor-associated macrophage function, leading to improved tumor microenvironment and potent inhibitory effect against immune checkpoint inhibition-resistant cancers.
In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor immune response. Nanoparticle-based delivery systems in cancer immunotherapy are of great interest in recent year. We have developed a novel cancer vaccine that can use selfassembled polysaccharide nanogel of cholesteryl group-modified pullulan (CHP) as an antigen delivery system for clinical cancer immunotherapy for the first time. Additionally, we recently proposed a novel technology that uses CHP nanogels to regulate the function of tumor-associated macrophages, leading to an improvement in the tumor microenvironment. When combined with other immunotherapies, macrophage function modulation using CHP nanogels demonstrated a potent inhibitory effect against cancers resistant to immune checkpoint inhibition therapies. In this review, we discuss the applications of our unique drug nanodelivery system for CHP nanogels.

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