4.7 Article

Drug delivery of memantine with carbon dots for Alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Disorder-to-order transition of the amyloid-/3 peptide upon lipid binding

Hebah Fatafta et al.

Summary: There is increasing evidence linking Alzheimer's disease progression and severity to neuronal membrane damage caused by aggregates of the amyloid-β (Aβ) peptide. The lipid-chaperone hypothesis suggests that complexes between Aβ and free lipids allow for easy insertion into membranes. However, experiments show that 1:1 complexes do not insert into membranes but rather adsorb to the membrane surface, with significant structural changes occurring when Aβ forms a complex with a cluster of lipid molecules.

BIOPHYSICAL CHEMISTRY (2022)

Article Thermodynamics

EFFECTS OF ETHANOL PORT INJECTION TIMING AND DELIVERY RATE ON COMBUSTION CHARACTERISTIC OF A HEAVY-DUTY V-12 DIESEL ENGINE

Kien Nguyen Trung et al.

Summary: This study investigates the effects of ethanol port injection timing and delivery rate on the combustion characteristic of a heavy-duty V-12 Diesel engine. The research finds that adjusting the ethanol injection timing and delivery rate can improve combustion and reduce emissions. The impact of changing ethanol injection timing is greater than that of ethanol delivery rate.

THERMAL SCIENCE (2022)

Article Biochemistry & Molecular Biology

Visualizing and trapping transient oligomers in amyloid assembly pathways

Emma E. Cawood et al.

Summary: Understanding the formation and toxicity mechanisms of oligomers during amyloid fibril assembly is crucial for amyloid diseases. By utilizing methods such as NMR, mass spectrometry, and tools to manipulate the amyloid energy landscape, researchers can gain insights into the nature and role of these oligomeric intermediates. These approaches allow for the study of kinetics, structural information, and structure-toxicity relationships of oligomers, providing a clearer picture of their contribution to amyloid formation and disease.

BIOPHYSICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology

Magdalena I. Ivanova et al.

Summary: Abnormal protein aggregation into filamentous amyloids is commonly associated with diseases like Alzheimer's and Parkinson's. Cross-seeding, where abnormal structures are propagated to other protein monomers, has become a key focus of research with a high volume of published reports. This mechanism not only contributes to understanding disease pathology but also aids in the formation of physiological amyloids.

BIOPHYSICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

The role of surfaces on amyloid formation

Fulvio Grigolato et al.

Summary: Interfaces can have a significant impact on protein aggregation behavior, with the molecular mechanism behind this process still not fully understood due to numerous physico-chemical parameters at play. The key factor determining protein aggregation at interfaces is the relative propensity compared to bulk phases. Combining experimental techniques with theoretical modeling is essential for gaining insights into the molecular mechanisms underlying surface-induced protein aggregation.

BIOPHYSICAL CHEMISTRY (2021)

Article Chemistry, Physical

A deep investigation into the structure of carbon dots

Keenan J. Mintz et al.

Summary: Carbon dots have been studied for their structure and properties, comparing three promising types in biomedicine to develop structural models for each nanosystem. The data revealed that black CDs and carbon nitride dots are more functionalized, disordered, and amorphous compared to yellow CDs. These models can be used to analyze CD emission properties and understand the structure-property relationship in CDs.

CARBON (2021)

Review Chemistry, Multidisciplinary

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Phuong H. Nguyen et al.

Summary: Protein misfolding and aggregation are common in amyloidogenic diseases, and understanding how amyloid species become toxic is crucial for treatment development. Experiments using computer modeling, in vitro and in vivo studies, as well as pharmacology, have provided valuable insights into the accumulation and deposition of amyloid species, contributing to research on diseases like Alzheimer's, Parkinson's, diabetes, and ALS.

CHEMICAL REVIEWS (2021)

Review Nanoscience & Nanotechnology

Carbon Dots: A Future Blood-Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Wei Zhang et al.

Summary: Nanoparticles, especially carbon dots, show unprecedented potential for drug delivery across the blood-brain barrier, offering hope for treating central nervous system diseases. With abundant functional groups on their surface, they can conjugate with diverse drugs to form versatile drug nanocarriers.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Chemistry, Physical

Metformin derived carbon dots: Highly biocompatible fluorescent nanomaterials as mitochondrial targeting and blood-brain barrier penetrating biomarkers

Emel Kirbas Cilingir et al.

Summary: This study synthesized metformin derived carbon dots (Met-CDs) with low toxicity and excellent biocompatibility, making them ideal candidates for bioimaging studies. Furthermore, Met-CDs were shown to penetrate cell membranes and localize in the nucleus and mitochondria, with potential selective targeting of cancer cell mitochondria. Zebrafish study confirmed Met-CDs crossing the blood-brain barrier without additional ligands.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Biochemistry & Molecular Biology

The folding space of protein β2-microglobulin is modulated by a single disulfide bridge

Jules Morand et al.

Summary: Discrete molecular dynamics simulations were used to explore the role of the disulfide bridge in beta-2-microglobulin folding space modulation, revealing its influence on the folding dynamics and thermodynamics of different model systems. The formation of an intermediate state with a well-preserved core due to stabilized or locked sulfur atom interactions has important implications for understanding beta 2m fibrillogenesis.

PHYSICAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Effect of tert-alcohol functional imidazolium salts on oligomerization and fibrillization of amyloid β (1-42) peptide

Madhukar S. Said et al.

BIOPHYSICAL CHEMISTRY (2020)

Article Clinical Neurology

Current and Future Treatments in Alzheimer's Disease

Alireza Atri

SEMINARS IN NEUROLOGY (2019)

Article Chemistry, Multidisciplinary

Preparation of Multicolor Photoluminescent Carbon Dots by Tuning Surface States

Kai Jiang et al.

NANOMATERIALS (2019)

Article Biochemical Research Methods

Carbon Nitride Dots: A Selective Bioimaging Nanomaterial

Piumi Y. Liyanage et al.

BIOCONJUGATE CHEMISTRY (2019)

Review Neurosciences

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options

Jeffrey L. Cummings et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Chemistry, Multidisciplinary

Triple conjugated carbon dots as a nano-drug delivery model for glioblastoma brain tumors

Sajini D. Hettiarachchi et al.

NANOSCALE (2019)

Article Chemistry, Physical

Thermodynamics and reaction mechanism of urea decomposition

Steffen Tischer et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2019)

Article Clinical Neurology

Alzheimer's disease drug development pipeline: 2019

Jeffrey Cummings et al.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2019)

Review Chemistry, Multidisciplinary

Crossing the blood-brain barrier with nanoparticles

Yiqun Zhou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Neurosciences

Alzheimer's disease hypothesis and related therapies

Xiaoguang Du et al.

TRANSLATIONAL NEURODEGENERATION (2018)

Editorial Material Multidisciplinary Sciences

THE AMYLOID HYPOTHESIS ON TRAIL

Simon Makin

NATURE (2018)

Editorial Material Medicine, General & Internal

Why do so many clinical trials of therapies for Alzheimer's disease fail?

Roy M. Anderson et al.

LANCET (2017)

Article Multidisciplinary Sciences

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Mian Bi et al.

NATURE COMMUNICATIONS (2017)

Article Engineering, Multidisciplinary

Facile and Scalable Preparation of Fluorescent Carbon Dots for Multifunctional Applications

Dan Wang et al.

ENGINEERING (2017)

Article Clinical Neurology

Tau Positron Emission Tomographic Imaging in Aging and Early Alzheimer Disease

Keith A. Johnson et al.

ANNALS OF NEUROLOGY (2016)

Article Clinical Neurology

Why has therapy development for dementia failed in the last two decades?

Serge Gauthier et al.

ALZHEIMERS & DEMENTIA (2016)

Article Biophysics

Crossing the blood-brain-barrier with transferrin conjugated carbon dots: A zebrafish model study

Shanghao Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

LANCET (2016)

Article Chemistry, Physical

Nontoxic Carbon Dots Potently Inhibit Human Insulin Fibrillation

Shanghao Li et al.

CHEMISTRY OF MATERIALS (2015)

Article Chemistry, Multidisciplinary

HPLC-Fluorescent Analysis of Memantine: An Investigation on Fluorescent Derivative Formation

Pornpan Prapatpong et al.

JOURNAL OF CHEMISTRY (2015)

Article Materials Science, Biomaterials

Swarming carbon dots for folic acid mediated delivery of doxorubicin and biological imaging

Ashmi Mewada et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

Review Multidisciplinary Sciences

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

Mathias Jucker et al.

NATURE (2013)

Article Materials Science, Biomaterials

Green synthesis of biocompatible carbon dots using aqueous extract of Trapa bispinosa peel

Ashmi Mewada et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

Article Neurosciences

A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

Wei Zhang et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Review Clinical Neurology

Modeling Neurodegeneration in Zebrafish

Yanwei Xi et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2011)

Article Chemistry, Multidisciplinary

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Sharmistha Sinha et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Biochemistry & Molecular Biology

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

Aimee M. Morris et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)

Article Chemistry, Multidisciplinary

Molecular clip and tweezer introduce new mechanisms of enzyme inhibition

Peter Talbiersky et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Chemistry, Multidisciplinary

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

Bruno Bulic et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

Review Biochemistry & Molecular Biology

Hacking the Code of Amyloid Formation The Amyloid Stretch Hypothesis

M. Teresa Pastor et al.

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Multidisciplinary Sciences

Tau is essential to β-amyloid-induced neurotoxicity

M Rapoport et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Evidence for a partially folded intermediate in α-synuclein fibril formation

VN Uversky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)