期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 617, 期 -, 页码 542-556出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2022.03.040
关键词
Photothermal effect; Antibacterial properties; Biofilm removal; O-2 generation; Diabetic wound healing
资金
- National Key Research and Development Program of China [2017YFB0309001]
- Natural Science Foundation of Shanghai [18ZR1400400, 18ZR1400500, 20ZR1402100]
- Fundamental Research Funds for Central Universities and Graduate Student Innovation Fund of Donghua University [CUSF-DH-D-2020026]
A multifunctional hydrogel platform has been developed to address the challenges of diabetic wound treatment by eliminating bacterial biofilm and relieving wound hypoxia. The hydrogel, with the addition of polydopamine and manganese dioxide, demonstrated excellent biocompatibility and wound healing properties.
Diabetic wound treatment remains a major challenge due to the difficulties of eliminating bacterial bio-film and relieving wound hypoxia. To address these issues simultaneously, a multifunctional Dex-SA-AEMA/MnO2/PDA (DSAMP) hydrogel platform was developed with excellent biocompatibility and porous structure. The hydrogel could absorb the exudate, maintain humidity and permeate oxygen, which was prepared by encapsulating polydopamine (PDA) and manganese dioxide (MnO2) into Dex-SA-AEMA (DSA) hydrogel by UV irradiation. With the addition of PDA, the DSAMP hydrogel was proved to eliminate the biofilm after NIR photodynamic therapy (PTT, 808 nm) irradiation at 54 degrees C. Furthermore, in order to mitigate hypoxia wound microenvironment, MnO2 nanoparticles were added to convert the endogenous hydrogen peroxide (H2O2) into oxygen (O-2 , 16 mg L-1). The diabetic wound in vivo treated by DSAMP hydrogel was completely healed on 14 days. It was revealed that the DSAMP hydrogel possessed a great potential as dressing for diabetic chronic wound healing. (C) 2022 Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据