A biocompatible bismuth based metal-organic framework as efficient light-sensitive drug carrier

The low toxicity and good photo active property endow bismuth based metal-organic frameworks (MOFs) potential candidates for efficient light-sensitive drug carrier. In this work, SU-101, composed of Bi and ellagic acid (EA), is found to display high ciprofloxacin (CIP) loading ratio (85.8%) and controlled CIP release under light illumination (the maximum CIP release ratio is 95.56%). Further investigations suggest that hydrogen bond between the C=O group in EA and the -OH group in CIP is responsible for above behavior. Light irradiation decreases the electron density around the C=O group in EA, which consequently leads to the broken of the hydrogen bond and therefore the release of CIP. Further investigations suggest that SU-101 is universal for other drugs, such as norfloxacin (NOR), amoxicillin (AMO), tetracycline (TET) and doxorubicin hydrochloride (DOX), since all of them can form hydrogen bond with SU-101. This work suggests that SU-101 holds great potential as efficient light-sensitive drug carrier, and the investigation of other Bi based MOFs as drug carrier is under investigation.(c) 2022 Elsevier Inc. All rights reserved.

Automated summary

Bismuth-based metal-organic framework SU-101 shows high drug loading and controlled drug release under light illumination, attributed to the hydrogen bond interaction between C=O and -OH groups. The study suggests the potential of SU-101 as a light-sensitive drug carrier for various drugs.