A reverse-transcription droplet digital PCR assay to detect and quantify SARS-CoV-2 RNA in upper respiratory tract specimens

Letter Immunology

College of American Pathologists (CAP) Microbiology Committee Perspective: Caution Must Be Used in Interpreting the Cycle Threshold (Ct) Value

Daniel Rhoads et al.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Pretest Symptom Duration and Cycle Threshold Values for Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-Transcription Polymerase Chain Reaction Predict Coronavirus Disease 2019 Mortality

Emily Happy Miller et al.

Summary: The study found that the viral load of SARS-CoV-2 and duration of symptoms in COVID-19 patients are closely associated with mortality. Patients with higher viral loads have a higher mortality rate, while those who seek medical attention shortly after symptom onset have a worse prognosis.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Immunology

SARS-CoV-2 Seroconversion and Viral Clearance in Patients Hospitalized With COVID-19: Viral Load Predicts Antibody Response

Mar Masia et al.

Summary: The study found that viral replication determines the magnitude of antibody response to SARS-CoV-2 in COVID-19 patients, which contributes to viral clearance. Some patients are unable to produce antibodies, exhibiting different virological and clinical profiles.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Pathology

Comparison of 12 Molecular Detection Assays for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Yasufumi Matsumura et al.

Summary: Molecular testing is crucial for accurate diagnosis of SARS-CoV-2 infection, with all assays showing 100% specificity and the N2 assays from the US Centers for Disease Control and Prevention and the Japanese National Institute of Infectious Disease being the most sensitive.

JOURNAL OF MOLECULAR DIAGNOSTICS (2021)

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Article Multidisciplinary Sciences