期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 42, 期 8, 页码 1730-1741出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-022-01341-2
关键词
Anti-GM-CSF; Autoantibody; Cryptococcus gattii; Pulmonary alveolar proteinosis; Anti-cytokine
类别
资金
- Chang Gung Memorial Hospital [CMRPG3G0811, CMRPG3L0961]
- Ministry of Science and Technology of Taiwan [MOST104-2314-B-182A-042, MOST105-2314-B-182A-033, MOST109-2628-B-182-014, MOST110-2628-B-182-018]
The study found high titers of neutralizing anti-GM-CSF Abs in some patients with C. gattii cryptococcosis, often with central nervous system involvement. However, investigation did not find an association between HLA and anti-GM-CSF Ab positivity.
Purpose Anti-granulocyte-macrophage colony-stimulating factor autoantibodies (anti-GM-CSF Abs) are a predisposing factor for pulmonary alveolar proteinosis (PAP) and Cryptococcus gattii cryptococcosis. This study aimed to investigate clinical manifestations in anti-GM-CSF Ab-positive patients with C. gattii cryptococcosis and analyze the properties of anti-GM-CSF Abs derived from these patients and patients with PAR. Methods Thirty-nine patients diagnosed with cryptococcosis (caused by C. neoformans or C. gattii) and 6 with PAP were enrolled in the present study. Clinical information was obtained from medical records. Blood samples were collected for analysis of autoantibody properties. We also explored the National Health Insurance Research Database (NHIRD) of Taiwan to investigate the epidemiology of cryptococcosis and PAP. Results High titers of neutralizing anti-GM-CSF Abs were identified in 15 patients with cryptococcosis (15/39, 38.5%). Most anti-GM-CSF Ab-positive cryptococcosis cases had central nervous system (CNS) involvement (14/15, 93.3%). Eleven out of 14 (78.6%) anti-GM-CSF Ab-positive CNS cryptococcosis patients were confirmed to be infected with C. gattii, and PAP did not occur synchronously or metachronously in a single patient from our cohort. Exploration of an association between HLA and anti-GM-CSF Ab positivity or differential properties of autoantibodies from cryptococcosis patients and PAP yielded no significant results. Conclusion Anti-GM-CSF Abs can cause two diseases, C. gattii cryptococcosis and PAP, which seldom occur in the same subject. Current biological evidence regarding the properties of anti-GM-CSF Abs cannot provide clues regarding decisive mechanisms. Further analysis, including more extensive cohort studies and investigations into detailed properties, is mandatory to better understand the pathogenesis of anti-GM-CSF Abs.
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