4.7 Article

Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Longitudinal changes in serum testosterone and sex hormone-binding globulin in men aged 40-69 years from the UK Biobank

Ross J. Marriott et al.

Summary: In relatively healthy middle-aged to older men, mean serum total testosterone concentration remains stable with aging, while mean SHBG concentration increases. Both total testosterone and SHBG concentrations show high concordance over time.

CLINICAL ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Maternal Polycystic Ovary Syndrome and Offspring Birth Weight: A Mendelian Randomization Study

Yuexin Gan et al.

Summary: This study used Mendelian randomization to investigate the causal effect of maternal PCOS on offspring birth weight, and found little evidence to support a significant impact of maternal PCOS on offspring weight.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Article Endocrinology & Metabolism

Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study

Romina Fornes et al.

Summary: Polycystic ovary syndrome (PCOS) during pregnancy is associated with increased risks of adverse pregnancy and perinatal outcomes as well as childhood obesity. Metformin appears to reduce these risks in mothers with PCOS and their children.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

The genetics of testosterone contributes to femaleness/maleness of cardiometabolic traits and type 2 diabetes

Daniel E. Vosberg et al.

Summary: The genetic architecture of testosterone varies significantly between males and females, with obesity and T2D risk being associated with sex-specific testosterone variants. Research conducted in the UK Biobank found that female-specific polygenic testosterone scores were linked to increased cardiometabolic risk and T2D probability, while male-specific scores were associated with decreased risk of cardiometabolic conditions and T2D.

INTERNATIONAL JOURNAL OF OBESITY (2022)

Article Obstetrics & Gynecology

Association of maternal polycystic ovary syndrome and diabetes with preterm birth and offspring birth size: a population-based cohort study

Xinxia Chen et al.

Summary: The presence of PCOS is associated with higher risks of total and spontaneous preterm birth in mothers with non-insulin-treated type 2 diabetes and GDM, while lower risk of offspring being LGA in mothers with insulin-treated diabetes.

HUMAN REPRODUCTION (2022)

Article Peripheral Vascular Disease

Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study

Maddalena Ardissino et al.

Summary: Mendelian randomization analysis revealed that higher systolic blood pressure, body mass index, and type 2 diabetes are causally associated with an increased risk of preeclampsia or eclampsia, while higher systolic blood pressure is also independently associated with reduced birthweight.

HYPERTENSION (2022)

Article Endocrinology & Metabolism

Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood

G. Huang et al.

Summary: Our study found that maternal androgen levels are associated with birth weight, particularly in girls. Furthermore, there are sex differences in the association of maternal androgens with fetal growth restriction. While there was no overall significant association between maternal androgens and weight trajectory, a significant sex interaction was observed with accelerated catch-up growth in boys.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

Article Obstetrics & Gynecology

Neonatal outcomes in women with polycystic ovary syndrome after frozen-thawed transfer

Jiaying Lin et al.

Summary: This study found that women with PCOS have higher odds of preterm birth after FET, but lower odds of low birth weight and SGA, especially in the subgroup with normal BMI.

FERTILITY AND STERILITY (2021)

Review Medicine, General & Internal

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement

Veronika W. Skrivankova et al.

Summary: The STROBE-MR Statement was developed to guide the reporting of MR studies by providing a checklist tailored to MR studies, which could improve the evaluation and interpretation of these studies by editors, peer reviewers, researchers, clinicians, and other readers.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Psychiatry

Contribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation

Massimiliano Orri et al.

Summary: The study found that low birth weight is associated with ADHD, PTSD, and suicide attempt, as well as intelligence and socioeconomic outcomes. However, there was no evidence of a contribution of birth weight to other mental health outcomes. These findings suggest that birth weight may play a role in determining mental health, cognitive, and socioeconomic outcomes.

BRITISH JOURNAL OF PSYCHIATRY (2021)

Article Multidisciplinary Sciences

Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study

Heiddis Valgeirsdottir et al.

Summary: Women with PCOS have a higher risk of extremely preterm birth, particularly with spontaneous onset, compared to women without PCOS. This information is important for antenatal risk assessment and further research on the biological mechanisms behind preterm birth in women with PCOS is needed.

PLOS ONE (2021)

Article Public, Environmental & Occupational Health

The use of two-sample methods for Mendelian randomization analyses on single large datasets

Cosetta Minelli et al.

Summary: Simulation studies found that two-sample MR methods used in one-sample MR performed well in handling confounding, except for MR-Egger method. The bias of MR-Egger method was greatly reduced when there was high variability in instrument strength.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2021)

Article Biochemistry & Molecular Biology

Using human genetics to understand the disease impacts of testosterone in men and women

Katherine S. Ruth et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits A Mendelian Randomization Study

Tao Huang et al.

JAMA NETWORK OPEN (2019)

Article Developmental Biology

Maternal salivary testosterone in pregnancy and fetal neuromaturation

Kristin M. Voegtline et al.

DEVELOPMENTAL PSYCHOBIOLOGY (2017)

Article Endocrinology & Metabolism

Sex steroids and the GH axis: Implications for the management of hypopituitarism

Vita Birzniece et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Genetics & Heredity

Bias due to participant overlap in two-sample Mendelian randomization

Stephen Burgess et al.

GENETIC EPIDEMIOLOGY (2016)

Article Endocrinology & Metabolism

Fertility and Pregnancy in Primary Adrenal Insufficiency in Germany

H. Remde et al.

HORMONE AND METABOLIC RESEARCH (2016)

Article Public, Environmental & Occupational Health

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

Stephen Burgess et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2015)

Article Obstetrics & Gynecology

Pregnancy complications in women with polycystic ovary syndrome

Stefano Palomba et al.

HUMAN REPRODUCTION UPDATE (2015)

Article Obstetrics & Gynecology

Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia

K. V. Naver et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2014)

Article Public, Environmental & Occupational Health

Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy

K. M. Voegtline et al.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2013)

Article Obstetrics & Gynecology

Fetal programming of adult hypertension in female rat offspring exposed to androgens in utero

K. Sathishkumar et al.

EARLY HUMAN DEVELOPMENT (2011)

Article Endocrinology & Metabolism

Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport

Kunju Sathishkumar et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2011)

Article Medicine, General & Internal

Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study

Nathalie Roos et al.

BMJ-BRITISH MEDICAL JOURNAL (2011)

Article Urology & Nephrology

The menopausal transition - Endocrinology

Henry Burger

JOURNAL OF SEXUAL MEDICINE (2008)

Review Mathematical & Computational Biology

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Debbie A. Lawlor et al.

STATISTICS IN MEDICINE (2008)

Article Endocrinology & Metabolism

Maternal testosterone levels during pregnancy are associated with offspring size at birth

S. M. Carlsen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2006)

Article Endocrinology & Metabolism

Diagnosis of hyperandrogenism: clinical criteria

Bulent O. Yildiz

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Obstetrics & Gynecology

Birth weight in offspring of mothers with polycystic ovarian syndrome

T Sir-Petermann et al.

HUMAN REPRODUCTION (2005)

Article Endocrinology & Metabolism

Androgen levels in adult females: Changes with age, menopause, and oophorectomy

SL Davison et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Article Endocrinology & Metabolism

Androgen excess in women: Experience with over 1000 consecutive patients

R Azziz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Article Medicine, General & Internal

Association between postnatal catch-up growth and obesity in childhood: prospective cohort study

KKL Ong et al.

BRITISH MEDICAL JOURNAL (2000)