期刊
JOURNAL OF CHEMICAL PHYSICS
卷 157, 期 3, 页码 -出版社
AIP Publishing
DOI: 10.1063/5.0098249
关键词
-
资金
- JSPS KAKENHI [JP21K03481]
Proteins containing a Bin/Amphiphysin/Rvs domain often have intrinsically disordered domains, which enhance curvature sensing and generation. Meshless membrane simulations show that disordered chains modify protein-membrane interactions and induce different shapes of vesicles and protein assemblies through repulsion effects.
Curvature-inducing proteins containing a Bin/Amphiphysin/Rvs domain often have intrinsically disordered domains. Recent experiments have shown that these disordered chains enhance curvature sensing and generation. Here, we report on the modification of protein-membrane interactions by disordered chains using meshless membrane simulations. The protein and bound membrane are modeled together as a chiral crescent protein rod with two excluded-volume chains. As the chain length increases, the repulsion between them reduces the cluster size of the proteins. It induces spindle-shaped vesicles and a transition between arc-shaped and circular protein assemblies in a disk-shaped vesicle. For flat membranes, an intermediate chain length induces many tubules owing to the repulsion between the protein assemblies, whereas longer chains promote perpendicular elongation of tubules. Moreover, protein rods with zero rod curvature and sufficiently long chains stabilize the spherical buds. For proteins with a negative rod curvature, an intermediate chain length induces a rugged membrane with branched protein assemblies, whereas longer chains induce the formation of tubules with periodic concave-ring structures. Published under an exclusive license by AIP Publishing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据