期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 42, 期 11, 页码 2066-2079出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X221108841
关键词
GlucoCESL; glucoCEST; cerebral glucose metabolism; kinetic modelling; brain tumours
资金
- Engineering and Physical Research Council [EP/M005909/1, EP/S031510/1]
- Medical Research Council Confidence in Concept Funding [MC_PC_17172]
- NIH [NS100703]
- EPSRC [EP/M005909/1, EP/S031510/1] Funding Source: UKRI
Chemical-exchange spin-lock (CESL) MRI is a useful technique for mapping glucose uptake and utilization in the brain. The study proposes two quantitative kinetic models to describe glucose-induced changes and applies them to tumor-bearing and healthy rats.
Chemical-exchange spin-lock (CESL) MRI can map regional uptake and utilisation of glucose in the brain at high spatial resolution (i.e sub 0.2 mm(3) voxels). We propose two quantitative kinetic models to describe glucose-induced changes in tissue R-1 rho and apply them to glucoCESL MRI data acquired in tumour-bearing and healthy rats. When assuming glucose transport is saturable, the maximal transport capacity (T-max) measured in normal tissue was 3.2 +/- 0.6 mu mol/min/mL, the half saturation constant (K-t) was 8.8 +/- 2.2 mM, the metabolic rate of glucose consumption (MRglc) was 0.21 +/- 0.13 mu mol/min/mL, and the cerebral blood volume (v(b)) was 0.006 +/- 0.005 mL/mL. Values in tumour were: T-max = 7.1 +/- 2.7 mu mol/min/mL, K-t = 14 +/- 1.7 mM, MRglc = 0.22 +/- 0.09 mu mol/min/mL, v(b) = 0.030 +/- 0.035 mL/mL. T-max and K-t were significantly higher in tumour tissue than normal tissue (p = 0.006 and p = 0.011, respectively). When assuming glucose uptake also occurs via free diffusion, the free diffusion rate (k(d)) was 0.061 +/- 0.017 mL/min/mL in normal tissue and 0.12 +/- 0.042 mL/min/mL in tumour. These parameter estimates agree well with literature values obtained using other approaches (e.g. NMR spectroscopy).
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