期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 42, 期 11, 页码 1979-1999出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X221113027
关键词
Neurovascular unit; blood-brain barrier; laminin; integrin; dystroglycan; cell-specific
资金
- National Institute of Health [R01HL146574, RF1AG065345, R21AG073862, R21AG064422]
This review focuses on the expression and functions of laminin and its receptors in the neurovascular unit under both physiological and pathological conditions. It discusses their roles in maintaining and repairing the blood-brain barrier (BBB) and identifies gaps in knowledge for future research.
Laminin, a major component of the basal lamina (BL), is a heterotrimeric protein with many isoforms. In the CNS, laminin is expressed by almost all cell types, yet different cells synthesize distinct laminin isoforms. By binding to its receptors, laminin exerts a wide variety of important functions. However, due to the reciprocal and cell-specific expression of laminin in different cells at the neurovascular unit, its functions in blood-brain barrier (BBB) maintenance and BBB repair after injury are not fully understood. In this review, we focus on the expression and functions of laminin and its receptors in the neurovascular unit under both physiological and pathological conditions. We first briefly introduce the structures of laminin and its receptors. Next, the expression and functions of laminin and its receptors in the CNS are summarized in a cell-specific manner. Finally, we identify the knowledge gap in the field and discuss key questions that need to be answered in the future. Our goal is to provide a comprehensive overview on cell-specific expression of laminin and its receptors in the CNS and their functions on BBB integrity.
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