期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 237, 期 6, 页码 2613-2631出版社
WILEY
DOI: 10.1002/jcp.30787
关键词
Cilia; Ciliopathy; Lipid; Lipid Modification; Signaling
资金
- Tata Institute of Fundamental Research [RTI4003]
Cilium, a tiny cellular appendage critical for cell signalling and physiology, has various receptors that determine cell behavior. This article examines the potential role of targeted changes in lipid composition in controlling receptor localization and function in cilia, and how it contributes to cilia growth and signaling.
Cilium, a tiny microtubule-based cellular appendage critical for cell signalling and physiology, displays a large variety of receptors. The composition and turnover of ciliary lipids and receptors determine cell behaviour. Due to the exclusion of ribosomal machinery and limited membrane area, a cilium needs adaptive logistics to actively reconstitute the lipid and receptor compositions during development and differentiation. How is this dynamicity generated? Here, we examine whether, along with the Intraflagellar-Transport, targeted changes in sector-wise lipid composition could control the receptor localisation and functions in the cilia. We discuss how an interplay between ciliary lipid composition, localised lipid modification, and receptor function could contribute to cilia growth and signalling. We argue that lipid modification at the cell-cilium interface could generate an added thrust for a selective exchange of membrane lipids and the transmembrane and membrane-associated proteins.
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