4.6 Article

Lessons learned: the first consecutive 1000 patients of the CCCMunichLMU Molecular Tumor Board

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Obstetrics & Gynecology

NGS-guided precision oncology in metastatic breast and gynecological cancer: first experiences at the CCC Munich LMU

Elena Sultova et al.

Summary: This study retrospectively evaluated the impact of personalized recommendations made by a multidisciplinary tumor board on the outcome of breast and gynecological cancer patients through comprehensive genomic profiling. The results showed that a small but significant portion of patients benefited from the genomic analysis, indicating challenges in the broad implementation of precision medicine due to late-stage referrals and limited access to targeted agents and early clinical trials.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2021)

Article Oncology

Routine application of next-generation sequencing testing in uro-oncology-Are we ready for the next step of personalised medicine?

Severin Rodler et al.

Summary: The aim of the study was to assess the feasibility and impact of routine NGS in personalized medicine for patients with genitourinary cancers. The results showed that NGS is increasingly feasible in clinical routine, with a growing number of tests performed and a decreasing turnaround time for therapy recommendations. However, challenges remain in terms of limited access to target agents for precision uro-oncology implementation.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Peter Horak et al.

Summary: Comprehensive molecular analysis in rare cancers can lead to evidence-based management recommendations and significantly improved clinical outcomes, paving the way for future clinical trials and potentially improving access to experimental treatments for this underserved patient population.

CANCER DISCOVERY (2021)

Article Endocrinology & Metabolism

Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study

Vivek Subbiah et al.

Summary: Pralsetinib is a new, well-tolerated, potent once-daily oral treatment option for patients with RET-altered thyroid cancer, showing significant antitumor activity and good safety profile in patients with different types of RET alterations.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Article Medicine, General & Internal

Efficacy of Selpercatinib in RET-Altered Thyroid Cancers

L. J. Wirth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, Research & Experimental

Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy

Louisa von Baumgarten et al.

THERANOSTICS (2020)

Editorial Material Oncology

Molecular screening to select therapy for advanced cancer?

I. F. Tannock et al.

ANNALS OF ONCOLOGY (2019)

Article Oncology

Variant classification in precision oncology

Jonas Leichsenring et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Oncology

The evidence framework for precision cancer medicine

Jeffrey A. Moscow et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Medicine, General & Internal

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children

A. Drilon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Challenging Standard-of-Care Paradigms in the Precision Oncology Era

Vivek Subbiah et al.

TRENDS IN CANCER (2018)

Article Oncology

Precision oncology based on omics data: The NCT Heidelberg experience

Peter Horak et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Review Oncology

Precision Oncology: Between Vaguely Right and Precisely Wrong

Amy Brock et al.

CANCER RESEARCH (2017)

Review Biochemistry & Molecular Biology

Implementing Genome-Driven Oncology

David M. Hyman et al.

Review Oncology

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials

Maria Schwaederle et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Medicine, General & Internal

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

Alice T. Shaw et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Survival in BRAF V600-Mutant Advanced Melanoma Treated with Vemurafenib

Jeffrey A. Sosman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)