4.4 Article

Spinal cord decellularized matrix scaffold loaded with engineered basic fibroblast growth factor-overexpressed human umbilical cord mesenchymal stromal cells promoted the recovery of spinal cord injury

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury

Yiwei Xu et al.

Summary: The repair of spinal cord injury depends on remodeling the microenvironment and supporting the recruitment and differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices have shown promise in promoting neural tissue regeneration, especially when derived from nervous system tissues. This study compared a DTM hydrogel derived from spinal cord (DSCM-gel) and one derived from peripheral nerves (DNM-gel), with results showing that DSCM-gel promotes NSPC viability, proliferation, migration, and differentiation into neurons in early 3D culturing stages.

BIOMATERIALS (2021)

Review Cell & Tissue Engineering

Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products

Miryam Mebarki et al.

Summary: UC-MSCs are considered as a promising perspective for treating immune and inflammatory diseases due to their immunomodulatory and anti-inflammatory properties. The classification of UC-MSC-based products as advanced therapy medicinal products in Europe poses challenges for stakeholders in terms of adaptation from cell banks to manufacturing medicines. Despite the potential, the development of UC-MSC-based ATMPs remains a real challenge for both academic institutions and pharmaceutical companies.

STEM CELL RESEARCH & THERAPY (2021)

Review Pharmacology & Pharmacy

Collagen-based scaffolds: An auspicious tool to support repair, recovery, and regeneration post spinal cord injury

Amina T. Mneimneh et al.

Summary: Collagen-based scaffolds play a significant role in promoting regeneration, repair, and recovery of spinal cord injuries by providing a suitable environment for tissue repair, axonal regeneration, and vascularization. They are biocompatible, biodegradable, and widely used in pharmaceutical, cosmetic, food industries, and tissue engineering. Functionalized with different ligands and factors, collagen in scaffolds enhances its binding specificity and activity.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Clinical Neurology

Acute Traumatic Spinal Cord Injury

Ilyas Eli et al.

NEUROLOGIC CLINICS (2021)

Article Cell & Tissue Engineering

Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Feifei Huang et al.

Summary: The study showed that bFGF-overexpressing HUCMSCs met clinical safety standards and significantly improved therapeutic outcomes in a mouse SCI model. This included reducing glial scar formation, enhancing nerve regeneration and NSC proliferation, and improving locomotion function recovery. Additionally, bFGF-overexpressing HUCMSCs promoted NSC proliferation and neuronal differentiation in vitro through the PI3K-Akt-GSK-3 beta pathway, supporting the safety and efficacy of gene-modified MSCs for clinical use.

STEM CELL RESEARCH & THERAPY (2021)

Article Materials Science, Biomaterials

Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair

Dingyang Liu et al.

Summary: A collagen scaffold, modified with Taxol liposomes and collagen-binding neurotrophic factor 3, was able to alleviate myelin-derived inhibition on neurite outgrowth and promote both axonal and neuronal regeneration in vitro and in a complete transected SCI model. The implanted scaffold facilitated the formation of neural bridging networks, leading to optimal neuroelectrophysiological recovery and hindlimb locomotor improvement in complete SCI rats.

BIOMATERIALS SCIENCE (2021)

Review Clinical Neurology

Recent update on basic mechanisms of spinal cord injury

Syed A. Quadri et al.

NEUROSURGICAL REVIEW (2020)

Review Biochemistry & Molecular Biology

Treatment of spinal cord injury with mesenchymal stem cells

Ling Ling Liau et al.

CELL AND BIOSCIENCE (2020)

Review Clinical Neurology

Modern Medical Management of Spinal Cord Injury

Michael Karsy et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

Article Cell & Tissue Engineering

Regenerative Therapies for Spinal Cord Injury

Nureddin Ashammakhi et al.

TISSUE ENGINEERING PART B-REVIEWS (2019)

Review Clinical Neurology

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

Thomas H. Hutson et al.

NATURE REVIEWS NEUROLOGY (2019)

Review Engineering, Biomedical

Combinatorial Therapies After Spinal Cord Injury: How Can Biomaterials Help?

Tobias Fuhrmann et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Review Neurosciences

Traumatic spinal cord injury: current concepts and treatment update

Carolina Rouanet et al.

ARQUIVOS DE NEURO-PSIQUIATRIA (2017)

Review Engineering, Biomedical

Extracellular matrix hydrogels from decellularized tissues: Structure and function

Lindsey T. Saldin et al.

ACTA BIOMATERIALIA (2017)

Article Multidisciplinary Sciences

Astrocyte scar formation aids central nervous system axon regeneration

Mark A. Anderson et al.

NATURE (2016)

Article Cell & Tissue Engineering

Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy

Dah-Ching Ding et al.

CELL TRANSPLANTATION (2015)

Article Multidisciplinary Sciences

Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats

Bo Chen et al.

SCIENTIFIC REPORTS (2015)

Article Cell & Tissue Engineering

Effects of Biologic Scaffolds on Human Stem Cells and Implications for CNS Tissue Engineering

Peter M. Crapo et al.

TISSUE ENGINEERING PART A (2014)

Article Engineering, Biomedical

Hydrogels derived from central nervous system extracellular matrix

Christopher J. Medberry et al.

BIOMATERIALS (2013)

Article Engineering, Biomedical

Biologic scaffolds composed of central nervous system extracellular matrix

Peter M. Crapo et al.

BIOMATERIALS (2012)

Article Cell & Tissue Engineering

Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair

Ting Liu et al.

TISSUE ENGINEERING PART A (2012)

Article Cell & Tissue Engineering

Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells

Tobias Deuse et al.

CELL TRANSPLANTATION (2011)

Article Engineering, Biomedical

Chitosan implants in the rat spinal cord: Biocompatibility and biodegradation

Howard Kim et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2011)

Article Cell & Tissue Engineering

Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells

Mark L. Weiss et al.

STEM CELLS (2008)