期刊
JOURNAL OF BIOLOGICAL RHYTHMS
卷 37, 期 4, 页码 385-402出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/07487304221092727
关键词
circadian; chronotherapy; intensive care; critical care; inflammation; acute respiratory distress syndrome; ventilator-associated lung injury; therapy; brain injury; multiorgan failure; critical illness; mitochondria; inflammasome; immunomodulation; cytokines; acute kidney injury; epigenetic
资金
- DWR MRC program [MR/P023576/1]
- Wellcome Trust [107849/Z/15/Z]
- Wellcome Trust [107849/Z/15/Z] Funding Source: Wellcome Trust
The Earth's 24-hour planetary rotation influences physiological mechanisms important for surviving critical illness, such as inflammation and energy metabolism. The cellular circadian clock regulates these mechanisms and has a significant impact on various diseases and overall mortality. Circadian medicine presents exciting opportunities for translational therapy in intensive care, addressing the current lack of treatment options.
The Earth's 24-h planetary rotation, with predictable light and heat cycles, has driven profound evolutionary adaptation, with prominent impacts on physiological mechanisms important for surviving critical illness. Pathways of interest include inflammation, mitochondrial function, energy metabolism, hypoxic signaling, apoptosis, and defenses against reactive oxygen species. Regulation of these by the cellular circadian clock (BMAL-1 and its network) has an important influence on pulmonary inflammation; ventilator-associated lung injury; septic shock; brain injury, including vasospasm; and overall mortality in both animals and humans. Whether it is cytokines, the inflammasome, or mitochondrial biogenesis, circadian medicine represents exciting opportunities for translational therapy in intensive care, which is currently lacking. Circadian medicine also represents a link to metabolic determinants of outcome, such as diabetes and cardiovascular disease. More than ever, we are appreciating the problem of circadian desynchrony in intensive care. This review explores the rationale and evidence for the importance of the circadian clock in surviving critical illness.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据