期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 298, 期 7, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jbc.2022.102118
关键词
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资金
- National Natural Science Foundation of China [32071163, 32070754]
- Natural Sci- ence Foundation of Chongqing, China [cstc2021ycjh- bgzxm0138, cstc2020jcyj-msxmX0714]
Sphingolipids are closely associated with aging and aging-related diseases, and they control aging by regulating lysosomal homeostasis and function. Studies show that sphingolipid-related diseases and aging share common mechanisms, potentially regulated through the lysosome.
Sphingolipids are a class of bioactive complex lipids that have been closely associated with aging and aging-related diseases. However, the mechanism through which sphingolipids control aging has long been a mystery. Emerging studies reveal that sphingolipids exert tight control over lysosomal homeostasis and function, as evidenced by sphingolipid-related diseases, including but not limited to lysosomal storage disorders. These diseases are defined by primary lysosomal defects and a few secondary defects such as mitochondrial dysfunction. Intriguingly, recent research indicates that the majority of these defects are also associated with aging, implying that sphingolipid-related diseases and aging may share common mechanisms. We propose that the lysosome is a pivotal hub for sphingolipid-mediated aging regulation. This review discusses the critical roles of sphingolipid metabolism in regulating various lysosomal functions, with an emphasis on how such regulation may contribute to aging and aging-related diseases.
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