4.6 Article

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork

Andre Franz et al.

Summary: The AAA(+)ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin, and cooperates with the deubiquitylase USP7 in DNA replication. The role of VCP in chromatin is defined by its cofactor FAF1, which facilitates the extraction of SUMOylated and ubiquitylated proteins. Inactivation of USP7 and FAF1 is synthetically lethal in C. elegans and mammalian cells, supporting a functional link between deubiquitylation and extraction of chromatin-bound proteins.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans

Yisui Xia et al.

Summary: The eukaryotic replisome disassembles during DNA replication termination, with the ubiquitin ligase CUL-2(LRR-1) driving CMG helicase ubiquitylation. The TIMELESS-TIPIN complex plays a crucial role in CUL-2(LRR-1) recruitment and efficient CMG helicase ubiquitylation. UBXN-3 adaptor protein stimulates the disassembly of ubiquitylated CMG, indicating its importance in replisome disassembly.

EMBO JOURNAL (2021)

Article Cell Biology

LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components

Yilin Fan et al.

Summary: Lack of LRR1 in human cells leads to failure in unloading replisomes, accumulation of replisome components, and reduction in DNA replication rate during S phase. Continued binding of CMG helicases to chromatin blocks mitosis by activating a G2/M checkpoint.

JOURNAL OF CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

Lin Deng et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

TRAIP is a master regulator of DNA interstrand crosslink repair

R. Alex Wu et al.

NATURE (2019)

Article Multidisciplinary Sciences

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

Edward C. Twomey et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

Nicolai B. Larsen et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy

Sang-Min Jang et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2018)

Review Biochemistry & Molecular Biology

The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97

Petra Haenzelmann et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2017)

Review Biochemistry & Molecular Biology

Control of p97 function by cofactor binding

Alexander Buchberger et al.

FEBS LETTERS (2015)

Article Multidisciplinary Sciences

The mechanism of DNA replication termination in vertebrates

James M. Dewar et al.

NATURE (2015)

Article Multidisciplinary Sciences

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

Sara Priego Moreno et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity

Marjo-Riitta Puumalainen et al.

NATURE COMMUNICATIONS (2014)

Review Cell Biology

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

Hemmo Meyer et al.

NATURE CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

Willem den Besten et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

Agnieszka Gambus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Hierarchical Binding of Cofactors to the AAA ATPase p97

Petra Haenzelmann et al.

STRUCTURE (2011)

Article Biochemistry & Molecular Biology

The Amino-Terminal TPR Domain of Dia2 Tethers SCFDia2 to the Replisome Progression Complex

Hiroko Morohashi et al.

CURRENT BIOLOGY (2009)

Article Multidisciplinary Sciences

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1α turnover

Gabriela Alexandru et al.

Article Biochemistry & Molecular Biology

Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition

Guennadi A. Khoudoli et al.

CURRENT BIOLOGY (2008)

Article Multidisciplinary Sciences

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

Stephen E. Moyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cell Biology

The F-box protein Dia2 regulates DNA replication

DM Koepp et al.

MOLECULAR BIOLOGY OF THE CELL (2006)

Article Biochemistry & Molecular Biology

A DNA integrity network in the yeast Saccharomyces cerevisiae

XW Pan et al.

Article Chemistry, Analytical

A statistical model for identifying proteins by tandem mass spectrometry

AI Nesvizhskii et al.

ANALYTICAL CHEMISTRY (2003)