Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context

Residual amounts of pyrethroids were detected in rice and vegetables of the Indian market. Thus, consumers are exposed to a mixture of pyrethroids on a daily basis through food. Though a large number of studies reported the toxic effects of pyrethroids, there are no reports that used doses equivalent to human consumption. In this study, male Wistar rats were exposed daily to a mixture of pyrethroids for 1-15 months which is equivalent to the amount present in rice and vegetables consumed by an average Indian each day. The oxidant-antioxidant status (lipid peroxidation, nitric oxide; activities of catalase, glutathione peroxidase, glutathione S transferase, and superoxide dismutase) and anatomical changes in the general organs (liver, lung, and kidney) and male reproductive tract tissues (caput, cauda, testis, and prostate) were evaluated. Further, liver and kidney function tests, lipid profile, and complete blood picture were analyzed. Increased oxidative stress, perturbations in the antioxidant enzyme activities, and damage to the anatomical architecture were observed. Disturbances in the liver function and lipid profile were significant. Results of our study demonstrate that exposure to a mixture of pyrethroids at a dose that is equivalent to human consumption can cause systemic and reproductive toxicity, which may ultimately result in the development of lifestyle diseases. This first line of evidence will fuel further studies to determine the impact of food-based pyrethroid exposure on the long-term health of humans and to envisage policies to reduce pesticide content in food products.

Automated summary

Residual amounts of pyrethroids were found in rice and vegetables in the Indian market, posing a daily exposure risk to consumers. A study on male Wistar rats exposed to pyrethroid mixture equivalent to human consumption levels revealed increased oxidative stress, disruptions in antioxidant enzyme activities, and anatomical damage to organs and male reproductive tissues. This exposure was also found to affect liver function and lipid profile. The findings indicate that exposure to pyrethroids present in food can lead to systemic and reproductive toxicity, emphasizing the need for further research and policy measures to reduce pesticide levels in food products.