期刊
JOURNAL OF BACTERIOLOGY
卷 204, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/jb.00197-22
关键词
methanogens; radical SAM; archaea; iron-sulfur cluster
类别
资金
- National Science Foundation [CHE-2105598]
Radical SAM enzymes play important roles in methanogenic archaea, which produce a significant amount of methane and encode many unknown functions of radical SAM enzymes. Understanding these enzymes can help reduce greenhouse gas emissions.
Radical S-adenosylmethionine (SAM) enzymes catalyze an impressive variety of difficult biochemical reactions in various pathways across all domains of life. These metalloenzymes employ a reduced [4Fe-4S] cluster and SAM to generate a highly reactive 5'-deoxyadenosyl radical that is capable of initiating catalysis on otherwise unreactive substrates. Interestingly, the genomes of methanogenic archaea encode many unique radical SAM enzymes with underexplored or completely unknown functions. These organisms are responsible for the yearly production of nearly 1 billion tons of methane, a potent greenhouse gas as well as a valuable energy source. Thus, understanding the details of methanogenic metabolism and elucidating the functions of essential enzymes in these organisms can provide insights into strategies to decrease greenhouse gas emissions as well as inform advances in bioenergy production processes. This minireview provides an overview of the current state of the field regarding the functions of radical SAM enzymes in methanogens and discusses gaps in knowledge that should be addressed.
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