HU Knew? Bacillus subtilis HBsu Is Required for DNA Replication Initiation

The prokaryotic nucleoid-associated protein (NAP) HU is both highly conserved and ubiquitous. Deletion of HU causes pleiotropic phenotypes, making it difficult to uncover the critical functions of HU within a bacterial cell. In their recent work, Karaboja and Wang (J Bacteriol 204:e00119-22, 2022, ) show that one essential function of Bacillus subtilis HU (HBsu) is to drive the DnaA-dependent initiation of DNA replication at the chromosome origin. We discuss the possible roles of HBsu in replication initiation and other essential cellular functions.

Automated summary

In this study, it was found that Bacillus subtilis HU (HBsu) plays a crucial role in driving DnaA-dependent initiation of DNA replication at the chromosome origin, revealing the importance of HU in replication initiation and other cellular functions.