Two new sesquiterpenoids from Dictyophora indusiata

Two new sesquiterpenoids, named 9,10-dihydroxy-albaflavenone (1) and 5-hydroxy-albaflavenone (2) were isolated from Dictyophora indusiata. Their structures and absolute configurations were determined by NMR, ECD and HRESIMS. Compounds 1 and 2 showed anti-inflammatory activity by inhibiting TNF-alpha and NO secretion to varying degrees.

Automated summary

In this study, two new sesquiterpenoids were isolated from Dictyophora indusiata, and their structures and absolute configurations were determined. The compounds, named 9,10-dihydroxy-albaflavenone (1) and 5-hydroxy-albaflavenone (2), exhibited anti-inflammatory activity by inhibiting the secretion of TNF-alpha and NO to varying degrees.