期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 139, 期 32, 页码 -出版社
WILEY
DOI: 10.1002/app.52760
关键词
biomaterials; drug delivery systems; nanoparticles; percutaneous delivery; polysaccharides
资金
- Al Ain University
This study aimed to develop and characterize nanoformulations made from modified pectin to enhance drug permeation through the skin. The results showed that the spherical nanostructures produced from modified pectin had controlled drug release and efficient cellular absorption, suggesting their potential for percutaneous delivery of poorly penetrating drugs.
The study aims to formulate and characterize nanoformulations produced from amphipathically-modified pectin containing fusidic acid, making clear the importance of nanocarrier amphipathicity in boosting drug permeation through the skin. For this purpose, the amphipathically-modified pectin (GBE-PEC) fabrication was achieved following glycidol butyl ether modification via the nucleophilic substitution S(N)2 reaction, which was then characterized using thermal analysis, spectroscopic, and chromatographic tools. The materials were subsequently converted into spherical nanostructures (NSs) (size 250-290 nm; zeta potential -25 to -34 mV) via a nanoprecipitation in situ cross-linking approach, demonstrating low viscosity and good colloidal stability under pH 4 conditions. The encapsulated fusidic acid (loading degree 14.9%) was released from GBE-PEC NSs in a more controlled fashion, with release profiles best characterized by the Higuchi model. Interactions with HaCaT cells in vitro demonstrated no apparent cytotoxicity at application relevant conditions, with efficient cellular absorption as evidenced by flow cytometry analysis. Using Franz diffusion cells, GBE-PEC NSs had a 2-fold greater penetration rate through the Strat-M (R) membrane than the native pectin NSs. Overall, the study has introduced new insights into the design, fabrication, characterization, and tremendous potential of NSs formulated from GBE-PEC for percutaneous delivery of poorly penetrating actives, which merit further analysis.
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