期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 89, 期 1, 页码 299-308出版社
IOS PRESS
DOI: 10.3233/JAD-220173
关键词
Accuracy; Alzheimer's disease; behavioral disorders; behavioral variant of frontotemporal dementia; diagnosis; frontal syndrome; frontotemporal dementia
资金
- Italian Association for Frontotemporal Dementia (AIMFT)
- Italian Ministry Ricerca Corrente 2022-2024
This study developed a short version of the Frontal Behavioral Inventory (mini-FBI) to identify early behavioral changes in behavioral variant of frontotemporal dementia (bvFTD) and aid in the differential diagnosis with Alzheimer's disease (AD). The mini-FBI consisted of 12 items and showed significant convergent validity with the Neuropsychiatric Inventory scores. Cluster analysis identified four clusters, with bvFTD and some AD patients showing similar behavioral patterns.
Background: The Frontal Behavioral Inventory (FBI) is a questionnaire designed to quantify behavioral changes in frontotemporal dementia (FTD). Literature showed heterogeneous FBI profiles in FTD versus Alzheimer's disease (AD) with variable occurrence of positive and negative symptoms. Objective: In this study, we constructed a short FBI version (i.e., mini-FBI) with the aim to provide clinicians with a brief tool for the identification of early behavioral changes in behavioral variant of FTD (bvFTD), also facilitating the differential diagnosis with AD. Methods: 40 bvFTD and 33 AD patients were enrolled. FBI items were selected based on internal consistency and exploratory factor analysis. Convergent validity of mini-FBIwas also assessed. A behavioral index (i.e., B-index) representing the balance between positive and negative mini-FBI symptoms was computed in order to analyze its distribution in bvFTD through a cluster analysis and to compare performance among patient groups. Results: The final version of the mini-FBI included 12 items, showing a significant convergent validity with the Neuropsychiatric Inventory scores (r(p) = 0.61, p < 0.001). Cluster analysis split patients in four clusters. bvFTD were included in three different clusters characterized by prevalent positive symptoms, both positive and negative symptoms, or prevalent negative behavioral alterations, similar to a subset of AD patients. A fourth cluster included only AD patients showing no positive symptoms. Conclusion: The mini-FBI is a valuable easily administrable questionnaire able to early identify symptoms effectively contributing to the bvFTD behavioral syndrome, aiding clinician in diagnosis and management.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据