4.7 Article

Pesticide Research and Development: General Discussion and Spinosad Case

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

NACHO permits functional heterologous expression of an insect homomeric α6 nicotinic acetylcholine receptor

Joseph Hawkins et al.

Summary: This study successfully achieved the functional expression of insect α6 subunit in heterologous systems using the chaperone protein NACHO for the first time. It also reported the functional expression of homomeric insect α6 nAChR for the first time. The results showed that the acetylcholine EC50 of the α6 receptor was 0.88 μM, and acetylcholine responses were antagonized by α-bungarotoxin. Furthermore, spinosad exhibited agonist actions and kept the ion channel open when co-applied with acetylcholine, confirming α6 nAChR subunit as a key molecular target for the spinosyn class of insecticide. The use of NACHO may provide a basis for future expression studies of insect α6 nAChRs, potentially providing a tool for the discovery of novel insecticides.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022)

Article Agronomy

Innovation in insecticide discovery: Approaches to the discovery of new classes of insecticides

Thomas C. Sparks et al.

Summary: The increasing demand for agrochemical insecticides has led to the development of new solutions for managing crop pest insects. Creating new classes of insecticidal molecules can stimulate improvements in spectrum, efficacy, and environmental impact. Understanding the origins and discovery approaches of first-in-class (FIC) insecticides provides insights for successful strategies in developing future FIC insecticides.

PEST MANAGEMENT SCIENCE (2022)

Review Agronomy

The spinosyns, spinosad, spinetoram, and synthetic spinosyn mimics - discovery, exploration, and evolution of a natural product chemistry and the impact of computational tools

Thomas C. Sparks et al.

Summary: Spinosyns, derived from soil inhibiting microorganisms, have been developed into various insect control products over the years with the help of artificial intelligence and computational tools. The recent synthetic spinosyn mimics have shown promising insecticidal effects against lepidopteran pests.

PEST MANAGEMENT SCIENCE (2021)

Article Biochemistry & Molecular Biology

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Trent Perry et al.

Summary: This study systematically investigates the insect response to different classes of insecticides and highlights the specificity of receptor subunits in insecticide resistance. The findings provide new insights into the mode of action of insecticides and reveal a strong conservation of subunit targets across different insect species.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Review Agronomy

Agrochemical industry development, trends in R&D and the impact of regulation

Matthew William Archer Phillips

PEST MANAGEMENT SCIENCE (2020)

Article Biochemistry & Molecular Biology

Insecticides, biologics and nematicides: Updates to IRAC's mode of action classification - a tool for resistance management

Thomas C. Sparks et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

New Frontiers on Human Safe Insecticides and Fungicides: An Opinion on Trehalase Inhibitors

Camilla Matassini et al.

MOLECULES (2020)

Article Neurosciences

Bifunctional opioid receptor ligands as novel analgesics

Christopher W. Cunningham et al.

NEUROPHARMACOLOGY (2019)

Review Entomology

Global trends in the crop protection industry

Ray Nishimoto

JOURNAL OF PESTICIDE SCIENCE (2019)

Review Chemistry, Medicinal

Biologically active quinoline and quinazoline alkaloids part I

Xiao-Fei Shang et al.

MEDICINAL RESEARCH REVIEWS (2018)

Article Multidisciplinary Sciences

Retrospective analysis of natural products provides insights for future discovery trends

Cameron R. Pye et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Insect trehalase: Physiological significance and potential applications

Ekta Shukla et al.

GLYCOBIOLOGY (2015)

Review Biochemistry & Molecular Biology

Insecticide discovery: An evaluation and analysis

Thomas C. Sparks

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2013)

Review Pharmacology & Pharmacy

COMBINATORIAL CHEMISTRY: A REVIEW

Anas Rasheed et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH (2013)

Review Biotechnology & Applied Microbiology

The spinosyn family of insecticides: realizing the potential of natural products research

Herbert A. Kirst

JOURNAL OF ANTIBIOTICS (2010)

Review Chemistry, Medicinal

Pest Toxicology: The Primary Mechanisms of Pesticide Action

John E. Casida

CHEMICAL RESEARCH IN TOXICOLOGY (2009)

Review Biotechnology & Applied Microbiology

Microbial drug discovery: 80 years of progress

Arnold L. Demain et al.

JOURNAL OF ANTIBIOTICS (2009)

Article Biochemistry & Molecular Biology

Novel mode of action of spinosad: Receptor binding studies demonstrating lack of interaction with known insecticidal target sites

Nailah Orr et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

Natural products as a screening resource

Alan L. Harvey

CURRENT OPINION IN CHEMICAL BIOLOGY (2007)