期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 32, 页码 9865-9876出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c02850
关键词
diabetic nephropathy; krill oil; fibrosis; SMAD; TGF-beta 1
资金
- National Natural Science Foundation of China [81973031, 82003447]
- Cheeloo Young Scholar Program of Shandong University [21320089963054]
- Young Scholars Program of Shandong University [2018WLJH33, 2018WLJH34]
- Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology [LMDBKF-2019-05]
The current study investigated the preventive effect of krill oil (KO) on diabetic nephropathy (DN) and found that it can prevent DN by suppressing the TGF-beta 1 signaling pathway.
Diabetic nephropathy (DN), a severe microvascular complication of diabetes mellitus (DM), results in high mortality due to the lack of effective interventions. The current study investigated the preventive effect of krill oil (KO) on DN using a type 2 DM mouse model induced by streptozotocin and high-fat diet for 24 weeks. The diabetic mice developed albuminuria, mesangial matrix accumulation, glomerular hypertrophy, and fibrosis formation, with an increase in renal proinflammatory, oxidative and profibrotic gene expression. KO significantly prevented these effects but did not improve hyperglycemia and glucose intolerance. In high-glucose-treated mesangial cells (MCs), KO preferably modulated TGF-beta 1 signaling as revealed by RNA-sequencing. In TGF-beta 1-treated MCs, KO abolished SMAD2/3 phosphorylation and nuclear translocation and activated Smad7 gene expression. The action of KO on the SMADs was confirmed in the diabetic kidneys. Therefore, KO may prevent DN predominantly by suppressing the TGF-beta 1 signaling pathway.
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