☆ 4.1 Review

Optimal use of the FDG-PET/CT in the diagnostic process of fever of unknown origin (FUO): a comprehensive review

JAPANESE JOURNAL OF RADIOLOGY (2022)

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Article Medicine, General & Internal

Diagnostic performance of 18F-FDG-PET/CT in inflammation of unknown origin: A clinical series of 317 patients

Jan Holubar et al.

Summary: Among 317 IUO patients, noninfectious inflammatory diseases were the major diagnoses, and F-18-FDG-PET/CT was found to be helpful in the diagnostic strategy. Polymyalgia rheumatica and giant cell arteritis were the top causes of noninfectious inflammatory diseases.

JOURNAL OF INTERNAL MEDICINE (2022)

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Review Medicine, General & Internal

Fever of Unknown Origin

Ghady Haidar et al.

Summary: Fever of unknown origin (FUO) refers to a fever higher than 38.3 degrees C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory tests. Infection, neoplasm, and noninfectious inflammatory diseases are the most common causes, but up to 50% of cases remain undiagnosed. FDG-PET is a commonly used diagnostic method that can detect malignancy, inflammation, and infection. However, it does not seem to contribute to a final diagnosis in patients with normal erythrocyte sedimentation rate and C-reactive protein.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Multidisciplinary Sciences

Diagnostic value of F-18 FDG PET/CT in fever or inflammation of unknown origin in a large single-center retrospective study

Friedrich Weitzer et al.

Summary: This study evaluates the value of F-18 FDG PET/CT in determining the cause of fever or inflammation of unknown origin. The findings suggest that PET/CT has a high sensitivity and specificity in diagnosing the cause, and it can potentially impact the treatment plan.

SCIENTIFIC REPORTS (2022)

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Article Medicine, General & Internal

Diagnostic Value of 18F-FDG PET/CT vs. Chest-Abdomen-Pelvis CT Scan in Management of Patients with Fever of Unknown Origin, Inflammation of Unknown Origin or Episodic Fever of Unknown Origin: A Comparative Multicentre Prospective Study

Kim-Heang Ly et al.

Summary: This study investigated the diagnostic value of Fluorodesoxyglucose Positron Emission Tomography (PET/CT) compared to Chest-Abdomen-Pelvis CT (CAPCT) in patients with a fever of unknown origin (FUO), inflammation of unknown origin (IUO), and episodic fever of unknown origin (EFUO). The results showed that PET/CT had a higher diagnostic guidance and contribution compared to CAPCT and reduced the time for diagnosis in patients.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Current situation and cost-effectiveness of 18F-FDG PET/CT for the diagnosis of fever of unknown origin and inflammation of unknown origin: A single-center, large-sample study from China

Jin-Chuan Chen et al.

Summary: The purpose of this study was to investigate the current status and cost-effectiveness of F-18-FDG PET/CT in the diagnostic work-up of FUO/IUO in China. The study found that F-18-FDG PET/CT is mostly used in critically-ill and hard-to-diagnose patients. Early use of F-18-FDG PET/CT can reduce hospitalization stay, limit medical costs, and improve the accuracy of etiological diagnosis.

EUROPEAN JOURNAL OF RADIOLOGY (2022)

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Review Pediatrics

Quantifying the contribution of 18F-FDG PET to the diagnostic assessment of pediatric patients with fever of unknown origin: a systematic review and meta-analysis

Qianrui Li et al.

Summary: This study aimed to evaluate the role of F-18-fluorodeoxyglucose positron emission tomography (PET) in pediatric fever of unknown origin. The results showed that pediatric patients with abnormal PET findings were about 17 times more likely to achieve definite diagnoses than those with normal PET findings. This suggests the potential value of F-18-fluorodeoxyglucose PET in the diagnostic assessment of pediatric fever of unknown origin.

PEDIATRIC RADIOLOGY (2022)

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Article Rheumatology

Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography for the Evaluation of Patients With Inflammation of Unknown Origin

Reyhan Bilici Salman et al.

Summary: The study aimed to evaluate the diagnostic role of positron emission tomography/computed tomography (PET/CT) in patients with Inflammation of Unknown Origin (IUO). PET/CT aided in diagnosing inflammatory rheumatic diseases in patients, but its effectiveness varied and had limitations in terms of sensitivity, specificity, and diagnostic accuracy.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of18F-FDG PET/CT and67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan

Kazuo Kubota et al.

Summary: This study aimed to compare the sensitivity of FDG-PET/CT with that of(67)Ga-SPECT for identifying the site of greatest importance for the final diagnosis of FUO, and found that FDG-PET/CT had significantly higher sensitivity and clinical impact compared to(67)Ga-SPECT.

ANNALS OF NUCLEAR MEDICINE (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Massimiliano Casali et al.

Summary: The clinical use of [F-18]FDG PET/CT or PET/MRI in assessing inflammation and infection is increasing globally. This paper aims to achieve an Italian consensus document on the application of [F-18]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, covering various conditions such as osteomyelitis, prosthetic joint infections, and COVID-19 infections.

CLINICAL AND TRANSLATIONAL IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Should FDG PET/CT or PET/MR replace WBC scan in infectious and inflammatory disease?

Luca Burroni et al.

CLINICAL AND TRANSLATIONAL IMAGING (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Diagnostic value of [18F]FDG-PET/CT in polymyalgia rheumatica: a systematic review and meta-analysis

K. S. M. van der Geest et al.

Summary: [18F]FDG-PET/CT scanning can effectively diagnose polymyalgia rheumatica by identifying significant uptake of FDG at specific anatomic sites. The technique shows promise as an important diagnostic tool for patients with suspected PMR, but standardized interpretation criteria and procedural recommendations are necessary for its use.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Optimal use of [18F]FDG-PET/CT in patients with fever or inflammation of unknown origin

Catharina M. Mulders-Manders et al.

Summary: [F-18]FDG-PET/CT plays a significant role in diagnosing patients with FUO/IUO, contributing to the final diagnosis in 45.2% of cases. However, it is not effective in patients with normal inflammatory parameters and body temperature. Repeating [F-18]FDG-PET/CT should be considered only when new symptoms appear or when the first scan was conducted without fever or elevated inflammatory parameters.

QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

At Last, 18F-FDG for Inflammation and Infection!

Richard L. Wahl et al.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Environmental Sciences

The Utility of 18FDG-PET/CT in Diagnosing Fever of Unknown Origin: The Experience of a Large Tertiary Medical Center

Hussein Mahajna et al.

Summary: This study evaluated the diagnostic yield of 18FDG-PET/CT in the work-up of FUO and found that the test is particularly effective in diagnosing patients with anemia and weight loss, with a high accuracy rate for FUO diagnosis.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Medicine, General & Internal

The yield of F18 FDG PET-CT for the investigation of fever of unknown origin, compared with diagnostic CT

S. Buchrits et al.

Summary: The study found that PET-CT has higher sensitivity but slightly lower specificity compared to CT in diagnosing classical FUO. In cases where endovascular infection, hematological malignancy, or large vessel vasculitis are suspected, PET-CT is recommended as the preferred imaging modality.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Characteristics and Clinical Value of 18F-FDG PET/CT in the Management of Adult-Onset Still's Disease: 35 Cases

Josselin Brisset et al.

Summary: The retrospective study showed that 18F-Fluorodeoxyglucose Positron Emission Tomography coupled with CT (PET/CT) has a certain value in the management of adult-onset Still's disease (AOSD), especially in aiding the exclusion of differential diagnoses and guiding biopsies.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Place of the 18F-FDG-PET/CT in the Diagnostic Workup in Patients with Classical Fever of Unknown Origin (FUO)

Simon Letertre et al.

Summary: The study analyzed the diagnostic contribution of F-18-FDG-PET/CT in 44 patients with FUO, showing that F-18-FDG-PET/CT was helpful for making a final diagnosis, especially in anemic patients. Most patients underwent CT scans and echocardiography before F-18-FDG-PET/CT, and biopsies and MRIs were mainly performed after F-18-FDG-PET/CT.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Utility of positron emission tomography-computed tomography in the evaluation of fever of unknown origin in a resource-limited tropical nation

Sohini Das et al.

Summary: PET-CT is a valuable tool in the evaluation of FUO, especially in resource-limited settings, with high sensitivity and positive predictive value. High CRP and AST levels were found to be predictors of contributory PET-CT scans, which were able to establish a definite diagnosis in majority of cases, primarily for infectious diseases.

WORLD JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Medicine, General & Internal

Predictors of Diagnostic Contributions and Spontaneous Remission of Symptoms Associated with Positron Emission Tomography with Fluorine-18-Fluorodeoxy Glucose Combined with Computed Tomography in Classic Fever or Inflammation of Unknown Origin: a Retrospective Study

Seiichiro Tsuzuki et al.

Summary: This study found that proposed variables were not predictive for successful localization by FDG-PET/CT in patients with unexplained fever or inflammation. A negative FDG-PET/CT scan may be prognostic for spontaneous remission in these patients.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Role of FDG-PET/CT in children with fever of unknown origin

Jordy P. Pijl et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

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Article Infectious Diseases

Combined clinical parameters improve the diagnostic efficacy of 18F-FDG PET/CT in patients with fever of unknown origin (FUO) and inflammation of unknown origin (IUO): A prospective study in China

Wen-Xia Wang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Immunology

Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma

William F. Wright et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Diagnostic Value of18F-FDG-PET/CT in Patients with FUO

Stamata Georga et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Contribution of 18F-FDG PET/CT in a case-mix of fever of unknown origin and inflammation of unknown origin: a meta-analysis

Ying Kan et al.

ACTA RADIOLOGICA (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Contribution of PET imaging to mortality risk stratification in candidates to lead extraction for pacemaker or defibrillator infection: a prospective single center study

Igor Diemberger et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDGPET/CT in fever of unknown origin and inflammation of unknown origin: a Chinese multi-center study

Qian Wang et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

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Article Infectious Diseases

Clinical features and outcomes of patients with fever of unknown origin: a retrospective study

Yuting Tan et al.

BMC INFECTIOUS DISEASES (2019)

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FDG PET/CT of Infection: Should It Replace Labeled Leukocyte Scintigraphy of Inpatients?

Elizabeth H. Dibble et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2019)

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Article Medicine, General & Internal

Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study

Toshio Naito et al.

BMJ OPEN (2019)

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Article Medicine, General & Internal

Long-term prognosis, treatment, and outcome of patients with fever of unknown origin in whom no diagnosis was made despite extensive investigation A questionnaire based study

Catharina M. Mulders-Manders et al.

MEDICINE (2018)

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Fever of Unknown Origin: the Value of FDG-PET/CT

Ilse J. E. Kouijzer et al.

SEMINARS IN NUCLEAR MEDICINE (2018)

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Evaluation of predictor variables of diagnostic [18F] FDG-PET/CT in fever of unknown origin

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Association of F-18-FDG PET or PET/CT results with spontaneous remission in classic fever of unknown origin A systematic review and meta-analysis

Motoki Takeuchi et al.

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Do clinical and laboratory variables have any impact on the diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin?

Ana Maria Garcia-Vicente et al.

ANNALS OF NUCLEAR MEDICINE (2018)

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The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study

Verena Schoenau et al.

ANNALS OF THE RHEUMATIC DISEASES (2018)

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The efficacy of 18F-FDG PET/CT and 67Ga SPECT/CT in diagnosing fever of unknown origin

Bor-Tau Hung et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2017)

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18F-FDG PET/CT Optimizes Treatment in Staphylococcus Aureus Bacteremia and Is Associated with Reduced Mortality

Marvin A. H. Berrevoets et al.

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Does Antibiotic Treatment Affect the Diagnostic Accuracy of 18F-FDG PET/CT Studies in Patients with Suspected Infectious Processes?

Olga Kagna et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

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Miguel A. Gonzalez-Gay et al.

LANCET (2017)

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Andrea Censullo et al.

OPEN FORUM INFECTIOUS DISEASES (2017)

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Diagnostic yield of FDG-PET/CT in fever of unknown origin: a systematic review, meta-analysis, and Delphi exercise

T. Bharucha et al.

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Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

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JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2016)

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A. Loizidou et al.

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Contribution of 18F-FDG PET in the diagnostic assessment of fever of unknown origin (FUO): a stratification-based meta-analysis

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Nuclear Imaging for Classic Fever of Unknown Origin: Meta-Analysis

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The diagnostic role of 18F fluorodeoxyglucose positron emission tomography in patients with fever of unknown origin

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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2015)

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18F-FDG PET/CT in inflammation of unknown origin: a cost-effectiveness pilot-study

H. Balink et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

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The Pathologic Findings of Skin, Lymph Node, Liver, and Bone Marrow in Patients With Adult-Onset Still Disease A Comprehensive Analysis of 40 Cases

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Tessa S. van Kempen et al.

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The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin

Hans Balink et al.

NUCLEAR MEDICINE COMMUNICATIONS (2015)

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Differences in fluorodeoxyglucose positron emission tomography/computed tomography findings between elderly onset rheumatoid arthritis and polymyalgia rheumatica

Hiroyuki Takahashi et al.

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Article Medicine, General & Internal

[18F]FDG-PET/CT for the diagnosis of patients with fever of unknown origin

A. Gafter-Gvili et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2015)

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Diagnostic utility of fluorodeoxyglucose positron emission tomography/computed tomography in pyrexia of unknown origin

Nidhi Singh et al.

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Sharon S. Evans et al.

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Utility of 18F-FDG PET/CT in Inflammation of Unknown Origin

Hans Balink et al.

CLINICAL NUCLEAR MEDICINE (2014)

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Article Medicine, General & Internal

Analysis of 256 Cases of Classic Fever of Unknown Origin

Masashi Yamanouchi et al.

INTERNAL MEDICINE (2014)

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Article Infectious Diseases

Diagnostic contribution of 18F-FDG-PET/CT in fever of unknown origin

Handan Tokmak et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2014)

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Article Multidisciplinary Sciences

Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients

Weimin Zhou et al.

PLOS ONE (2014)

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Mortality in patients presenting with fever of unknown origin

S. Vanderschueren et al.

ACTA CLINICA BELGICA (2014)

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Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever

Joachim Roth et al.

COMPREHENSIVE PHYSIOLOGY (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

F-18 FDG-PET/CT in evaluation of patients with fever of unknown origin

Kuruva Manohar et al.

JAPANESE JOURNAL OF RADIOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

EANM/SNMMI Guideline for 18F-FDG Use in Inflammation and Infection

Francois Jamar et al.

JOURNAL OF NUCLEAR MEDICINE (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin: a meta-analysis

Ruirui Hao et al.

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Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study

Toshio Naito et al.

BMJ OPEN (2013)

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Article Rheumatology

2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative

Bhaskar Dasgupta et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

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Article Infectious Diseases

Place of 18F-FDG-PET with computed tomography in the diagnostic algorithm of patients with fever of unknown origin

J. Crouzet et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2012)

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Article Medicine, General & Internal

Clinical Features of 66 Lymphoma Patients Presenting with a Fever of Unknown Origin

Jing Zhang et al.

INTERNAL MEDICINE (2012)

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Article Medicine, General & Internal

Diagnostic value of 18F-FDG PET/CT in patients with fever of unknown origin

Y. J. Kim et al.

INTERNAL MEDICINE JOURNAL (2012)

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Article Infectious Diseases

Superiority of 18F-FDG PET compared to 111In-labelled leucocyte scintigraphy in the evaluation of fever of unknown origin

N. Seshadri et al.

JOURNAL OF INFECTION (2012)

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Article Infectious Diseases

Fever of unknown origin: A retrospective study of 52 cases with evaluation of the diagnostic utility of FDG-PET/CT

Thomas Ingemann Pedersen et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2012)

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Article Medicine, General & Internal

Diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with fever of unknown origin

Ji-Fang Sheng et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

A meta-analysis of the value of fluorodeoxyglucose-PET/PET-CT in the evaluation of fever of unknown origin

Meng-jie Dong et al.

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Cost-Effectiveness of Routine 18F-FDG PET/CT in High-Risk Patients with Gram-Positive Bacteremia

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Role of integrated PET/CT with [18F]-FDG in the management of patients with fever of unknown origin: a single-centre experience

E. Pelosi et al.

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Amy Chow et al.

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Value of F-18-FDG-PET/CT in patients with fever of unknown origin and unexplained prolonged inflammatory syndrome: a single centre analysis experience

L. Federici et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

[18F] FDG PET/CT in patients with fever of unknown origin: a local experience

Pin Lin Kei et al.

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Article Radiology, Nuclear Medicine & Medical Imaging

F-18 FDG PET/CT in the Diagnosis of Fever of Unknown Origin

Hans Balink et al.

CLINICAL NUCLEAR MEDICINE (2009)

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Article Medicine, General & Internal

Inflammation of unknown origin versus fever of unknown origin: Two of a kind

Steven Vanderschueren et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Fever of Unknown Origin: The Role of 18F-FDG PET/CT

Zohar Keidar et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

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Article Medicine, General & Internal

A prospective multicenter study on fever of unknown origin - The yield of a structured diagnostic protocol

Chantal P. Bleeker-Rovers et al.

MEDICINE (2007)

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Article Infectious Diseases

Fever of unknown origin in adults: Evaluation of 144 cases in a non- university hospital

Thierry Zenone

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2006)

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Review Radiology, Nuclear Medicine & Medical Imaging

Fever of unknown origin: a systematic review of the literature for 1995-2004

GB Gaeta et al.

NUCLEAR MEDICINE COMMUNICATIONS (2006)

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Review Medicine, General & Internal

Fever of unknown origin in adults: 40 years on

DC Knockaert et al.

JOURNAL OF INTERNAL MEDICINE (2003)

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Review Oncology

Molecular imaging of cancer with positron emission tomography

SS Gambhir

NATURE REVIEWS CANCER (2002)

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