期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 61, 期 3, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2022.5401
关键词
long noncoding RNA; tongue squamous cell carcinoma; cell cycle; microRNA 3180; GATA zinc finger domain containing 2A
类别
This study identified a novel lncRNA, lncKRT16P6, that is upregulated in TSCC and promotes metastasis and malignancy by regulating miR-3180 and GATAD2A expression. Therefore, lncKRT16P6 may serve as a prognostic biomarker and therapeutic target for TSCC.
Tongue squamous cell carcinoma (TSCC) is characterized by a poor prognosis and its 5-year overall survival rate has not improved significantly. However, the precise molecular mechanisms underlying TSCC remain largely unknown. Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade. Inhibition of lncKRT16P6 expression reduced TSCC cell migration, invasion and proliferation. lncKRT16P6 sponged microRNA (miR)-3180 and upregulated GATA zinc finger domain containing 2A (GATAD2A) expression. miR-3180 inhibition reversed the lncKRT16P6 depletion-induced attenuation of TSCC malignancy and GATAD2A depletion reversed the miR-3180 silencing-induced enhancement of TSCC malignancy. In summary, the present study revealed a potential competitive endogenous RNA (ceRNA) regulatory pathway in which lncKRT16P6 modulates GATAD2A expression by binding miR-3180, ultimately promoting tumorigenesis and metastasis in TSCC. Therefore, lncKRT16P6 may be used as a prognostic biomarker and therapeutic target for clinical intervention in TSCC.
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