4.7 Article

Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8+T Cell Response in HLA-A Transgenic Mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Dynamic SARS-CoV-2-specific B-cell and T-cell responses following immunization with an inactivated COVID-19 vaccine

Yuxin Chen et al.

Summary: This study analyzed the dynamic changes of immune responses after receiving the CoronaVac vaccine. The results showed that CoronaVac can effectively induce circulating and memory B cell and T cell immune responses. Age and interval between doses affect the magnitude of immune responses.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

Article Multidisciplinary Sciences

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Nina Koerber et al.

Summary: Anti-viral immunity declines over time after SARS-CoV-2 infection, but convalescents can achieve enhanced immune response through vaccination. Virus-specific antibody titers decline rapidly, while virus-specific polyfunctional T cells persist.

NATURE COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

Kensaku Murano et al.

Summary: The COVID-19 pandemic caused by the novel coronavirus has infected over 200 million people and resulted in 4.3 million deaths as of August 2021. Human-origin monoclonal antibodies have been isolated from convalescent patients for therapeutic and prophylactic purposes, while vaccines have been rapidly administered to restrict the spread of the virus. However, the emergence of new variants presents challenges to neutralizing antibodies and threatens the efficacy of current vaccines.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

Article Immunology

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8+ T cell responses in HLA-A transgenic mice

Xiaoxiao Jin et al.

Summary: This study validated multiple T cell epitopes related to SARS-CoV-2 and developed vaccines that induce specific T cell responses. Utilizing different combination strategies and immunogens, the vaccines successfully elicited robust and specific CD8(+) T cell responses.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

Mapping and role of T cell response in SARS-CoV-2-infected mice

Zhen Zhuang et al.

Summary: This study identified SARS-CoV-2-specific T cell epitopes and demonstrated the important role of virus-specific T cells in the immune response after SARS-CoV-2 infection, particularly in regulating immune responses. T cell vaccination alone partially protected SARS-CoV-2-infected mice from severe disease.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Virology

Identification of HLA-A*02:01-Restricted Candidate Epitopes Derived from the Nonstructural Polyprotein la of SARS-CoV-2 That May Be Natural Targets of CD8+ T Cell Recognition In Vivo

Akira Takagi et al.

Summary: In the development of vaccines based on SARS-CoV-2-specific cytotoxic T lymphocytes (CTLs), 55 CTL epitope candidates were identified, with 18 of them validated for their effectiveness in HLA-A*02:01 transgenic mice. 10 peptides with high responses were selected for further analysis to reveal an immunodominance hierarchy following peptide vaccination.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Sandile Cele et al.

Summary: The study compared the neutralization of non-VOC and 501Y.V2 VOC variants using plasma from COVID-19 patients in South Africa. It found that plasma from individuals infected during the first wave effectively neutralized the first-wave virus variant, while plasma from those infected in the second wave effectively neutralized the 501Y.V2 variant.

NATURE (2021)

Article Immunology

Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups

Hans-Georg Rammensee et al.

Summary: The study involved two vaccinations of a healthy volunteer with SARS-CoV-2-derived peptides, resulting in CD4 T cell responses against some peptides after 19 days. These findings support the design of a T-cell-inducing vaccine for high-risk patients with weakened lymphocyte function.

VACCINES (2021)

Review Pharmacology & Pharmacy

Extracellular vesicles as antigen carriers for novel vaccination avenues

Mina Mehanny et al.

Summary: EVs and MVs provide innovative avenues for safe and effective antigen delivery, with potential applications in anti-cancer vaccination immunotherapy and prophylactic vaccination against infectious diseases.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Infectious Diseases

The potential clinical utility of measuring severe acute respiratory syndrome coronavirus 2-specific T-cell responses

Delia Goletti et al.

Summary: T-cell responses play a crucial role in COVID-19, providing early detection of disease progression and predictive value for severity and survival rates. Vaccination stimulates robust T-cell responses, contributing significantly to protective immunity, although understanding of long-term T-cell responses remains limited.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Urology & Nephrology

Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI

Tao-Tao Tang et al.

Summary: Using engineered red blood cell-derived extracellular vesicles (REVs) to target Kim-1 and transcription factors P65 and Snai1, potential therapeutic targets, showed significant efficacy in treating experimental AKI in a mouse model, alleviating kidney injury.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Cell Biology

Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

Sai Priya Anand et al.

Summary: Recent research on convalescent individuals of COVID-19 has shown a decline in antibody levels in plasma, while specific memory B cells remain present. IgM antibodies against Spike and RBD decay rapidly, whereas IgG decline is less significant. Understanding these immune memory responses is crucial for secondary infection prevention and vaccine efficacy.

CELL REPORTS MEDICINE (2021)

Article Biochemistry & Molecular Biology

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Lin-Li Lv et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion

Wenjin Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

Editorial Material Immunology

An Effective COVID-19 Vaccine Needs to Engage T Cells

Karsten Sauer et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Cell Biology

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Lucie Rodriguez et al.

CELL REPORTS MEDICINE (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Medicine, Research & Experimental

Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

Tao-Tao Tang et al.

THERANOSTICS (2020)

Review Oncology

Immune responses during COVID-19 infection

Clea Melenotte et al.

ONCOIMMUNOLOGY (2020)

Article Pharmacology & Pharmacy

In vivo Non-invasive Imaging of Radio-Labeled Exosome-Mimetics Derived From Red Blood Cells in Mice

Prakash Gangadaran et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Chemistry, Multidisciplinary

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

Dhruvitkumar S. Sutaria et al.

PHARMACEUTICAL RESEARCH (2017)

Article Chemistry, Multidisciplinary

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

S. A. A. Kooijmans et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Multidisciplinary Sciences

Engineering hybrid exosomes by membrane fusion with liposomes

Yuko T. Sato et al.

SCIENTIFIC REPORTS (2016)

Article Urology & Nephrology

Transglutaminase 2 Accelerates Vascular Calcification in Chronic Kidney Disease

Neal X. Chen et al.

AMERICAN JOURNAL OF NEPHROLOGY (2013)