期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 17, 期 -, 页码 3511-3529出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S370767
关键词
sonodynamic therapy; multifunctional sonosensitizers; imaging; ultrasound
资金
- National Natural Science Foundation of China [81873900, 82171947]
Sonodynamic therapy (SDT) is a rapidly developing non-surgical therapy that uses ultrasound to initiate sensitizers' catalytic reaction, showing great potential for safe and non-invasive cancer treatment. Sonosensitizers, as essential components of SDT, have been extensively explored to optimize their functions and integrate multiple medical fields. Combining imaging and SDT has been found to lead to better anticancer outcomes.
Sonodynamic therapy (SDT) is a rapidly developing non-surgical therapy that initiates sensitizers' catalytic reaction using ultrasound, showing great potential for cancer treatment due to its high safety and non-invasive nature. In addition, recent research has found that using different diagnostic and therapeutic methods in tandem can lead to better anticancer outcomes. Therefore, as essential components of SDT, sonosensitizers have been extensively explored to optimize their functions and integrate multiple medical fields. The review is based on five years of articles evaluating the combined use of SDT and imaging in treating cancer. By developing multifunctional sonosensitive particles that combine imaging and sonodynamic therapy, we have integrated diagnosis into the treatment of precision medicine applications, improving SDT cell uptake and antitumor efficacy utilizing different tumour models. This paper describes the imaging principle and the results of cellular and animal imaging of the multifunctional sonosensitizers. Efforts are made in this paper to provide data and design references for future SDT combined imaging research and clinical application development and to provide offer suggestions.
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