Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2

Article Biochemistry & Molecular Biology

Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines

Yixuan Ma et al.

Summary: CK2 and CDK inhibitors showed efficacy on PDAC cell lines, but the sensitivity was not correlated with target gene expression or mutations. Specific mutations in TP53 and KRAS affected the efficacy of both inhibitors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Physiology

The Molecular Brakes of Adipose Tissue Lipolysis

Yongguo Li et al.

Summary: Adapting to changes in energy availability is crucial for animal survival. Adipose tissue serves as a buffer for fluctuations in nutrient availability by storing and mobilizing energy. The regulation of adipocyte lipolysis, the release of stored fats, is complex and involves various signaling pathways. Understanding these mechanisms is important for understanding metabolic diseases and developing therapies.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Physiology

Weighing in on Adipogenesis

Elizabeth R. Nunn et al.

Summary: Obesity has negative effects on health, including metabolic syndrome, type II diabetes, insulin resistance, and various cancers. Understanding the mechanisms of adipose tissue expansion is important for developing therapeutic approaches.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Biology

Expression and Role of beta 3-Adrenergic Receptor during the Differentiation of 3T3-L1 Preadipocytes into Adipocytes

Amir Roshanzadeh et al.

Summary: This study demonstrates that the expression of beta 3-adrenergic receptor (beta 3-AR) is up-regulated during differentiation of 3T3-L1 cells in a p38 MAPK and PKC-dependent manner, and plays a crucial role in lipid accumulation.

BIOLOGY-BASEL (2022)

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Article Biochemistry & Molecular Biology

Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2α, and HIF-1α

Saini Wang et al.

Summary: This study found that CX-4945 has anti-growth, anti-angiogenic, and proapoptotic effects on HuCCT-1 cells, which are mediated through the control of CK2, caspase-9/3, DR-4, STAT-3/5, Mcl-1, eIF-2 alpha, and HIF-1 alpha.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Endocrinology & Metabolism

Global pandemics interconnected - obesity, impaired metabolic health and COVID-19

Norbert Stefan et al.

Summary: Obesity and impaired metabolic health are established risk factors for NCDs such as type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer, and MAFLD, and have been linked to an increased risk of severe COVID-19. Specifically, visceral obesity and characteristics of impaired metabolic health are associated with a high risk of severe COVID-19.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Oncology

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia

Morgann Klink et al.

Summary: The study reveals that inhibition of CK2 kinase can enhance the efficacy of chemotherapy drugs in patients with acute myeloid leukemia, especially when used in combination with CX-4945 inhibitor. Additionally, CK2 inhibition can also restore the function of the IKAROS tumor suppressor, increasing the sensitivity of AML cells to apoptosis.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Inhibition of Lipid Accumulation and Cyclooxygenase-2 Expression in Differentiating 3T3-L1 Preadipocytes by Pazopanib, a Multikinase Inhibitor

Anil Kumar Yadav et al.

Summary: The study found that pazopanib significantly reduces lipid accumulation and triglyceride content during the differentiation of 3T3-L1 preadipocytes, while also inhibiting the occurrence of inflammation. This process is accompanied by the regulation of multiple key signaling pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease

Esmeralda Parra-Peralbo et al.

Summary: Adipose tissue is a dynamic organ responsible for energy storage and mobilization in the human body. It acts as the largest endocrine organ, secreting hormones and inflammatory molecules, and plays important roles in various processes such as adipogenesis, metabolism, and chronic inflammation. Drosophila melanogaster has been proven to be an excellent model for studying metabolism and the development of endocrine/metabolic organs, leading to discoveries in hormone regulation of obesity and subcellular mechanisms of lipogenesis and lipolysis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Anti-growth and pro-apoptotic effects of dasatinib on human oral cancer cells through multi-targeted mechanisms

Nam-Sook Park et al.

Summary: The study showed that dasatinib has strong anti-growth, anti-angiogenic, and pro-apoptotic effects on human oral cancer cells, mediated through the regulation of multiple targets including Src, EGFR, STAT-3, STAT-5, PKB, ERK-1/2, and others.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Protein kinase CK2: a potential therapeutic target for diverse human diseases

Christian Borgo et al.

Summary: CK2 is a constitutively active protein kinase with diverse roles in cancer, viral infections, cardiovascular diseases, and other human pathologies, making it a potential pharmacological target with specific inhibitors already available.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Multidisciplinary Sciences

The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet

Jessica E. C. Jones et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

Alexander Yang et al.

BIOCHEMICAL JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Bilal Ahmad et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Biochemistry & Molecular Biology

Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress

Anil Kumar Yadav et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways

Yuzhou Song et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Review Endocrinology & Metabolism

Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

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Article Biochemistry & Molecular Biology

AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK

Anil Kumar Yadav et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

AZD1208, a pan-Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3-L1 adipocytes

Yu-Kyoung Park et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Biology

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Sandra Galic et al.

ELIFE (2018)

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Review Endocrinology & Metabolism

Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex

Xinran Ma et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Review Biochemistry & Molecular Biology

Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction

Arunkumar E. Achari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Chemistry, Medicinal

Inhibition of Protein Kinase CK2 Prevents Adipogenic Differentiation of Mesenchymal Stem Cells Like C3H/10T1/2 Cells

Lisa Schwind et al.

PHARMACEUTICALS (2017)

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Review Medicine, Research & Experimental

Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity

Mark Hopkins et al.

CLINICAL SCIENCE (2016)

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Article Endocrinology & Metabolism

Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet

L. Parrillo et al.

INTERNATIONAL JOURNAL OF OBESITY (2016)

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Review Biochemistry & Molecular Biology

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

David Albuquerque et al.

MOLECULAR GENETICS AND GENOMICS (2015)

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Review Endocrinology & Metabolism

Adipokines - removing road blocks to obesity and diabetes therapy

Matthias Blueher

MOLECULAR METABOLISM (2014)

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Article Medicine, General & Internal

Biochemistry of adipose tissue: an endocrine organ

Marisa Coelho et al.

ARCHIVES OF MEDICAL SCIENCE (2013)

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Review Medical Laboratory Technology

Role of leptin and adiponectin in insulin resistance

Amita Yadav et al.

CLINICA CHIMICA ACTA (2013)

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Article Cell Biology

Adipocyte and adipogenesis

Aus Tariq Ali et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2013)

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Article Endocrinology & Metabolism

PKC and ERK mediate GH-stimulated lipolysis

Heather E. Bergan et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2013)

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Article Cell Biology

Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes

Nadine Wilhelm et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

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Article Cell Biology

Adipogenesis

Kelesha Sarjeant et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Review Biochemistry & Molecular Biology

Lipolysis - A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

Achim Lass et al.

PROGRESS IN LIPID RESEARCH (2011)

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Article Endocrinology & Metabolism

Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes

Tingting Zhang et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2009)

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Article Cell Biology

PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation

Claudia N. Martini et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

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Article Cell Biology

AMPK and ACC phosphorylation:: Effect of leptin, muscle fibre type and obesity

A. Janovska et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)

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Review Biochemistry & Molecular Biology

AMPK: a metabolic gauge regulating whole-body energy homeostasis

Ricardo Lage et al.

TRENDS IN MOLECULAR MEDICINE (2008)

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Article Biochemistry & Molecular Biology

Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP

Rebecca L. Hurley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Review Biochemistry & Molecular Biology

A proposed model of fat packaging by exchangeable lipid droplet proteins

Nathan E. Wolins et al.

FEBS LETTERS (2006)

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Article Pharmacology & Pharmacy

AMP-activated protein kinase - the fat controller of the energy railroad

Gregory R. Steinberg et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2006)

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Article Endocrinology & Metabolism

Perilipin expression in human adipose tissue is elevated with obesity

PA Kern et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

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Article Cell Biology

Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation

C Sztalryd et al.

JOURNAL OF CELL BIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα gene expression during the differentiation of 3T3-L1 preadipocytes

D Prusty et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2

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