期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms23126479
关键词
intracerebral hemorrhage; genetics; epigenetics
资金
- Spain's Ministry of Health (Instituto de Salud Carlos III, Fondos FEDER) [RICORS-ICTUS RD21/0006/0021]
- Juan Rodes research contract [JR18/00004]
This review summarizes the advances in genetics and epigenetics of intracerebral hemorrhage (ICH), shedding light on the understanding of ICH pathophysiology and the potential for developing therapeutic strategies.
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
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