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Review
Biochemistry & Molecular Biology
Anna S. Fefilova et al.
Summary: Stress is an inevitable part of life, and organisms have developed mechanisms to combat stress, including the assembly of stress-induced membraneless organelles. These organelles serve to protect the genetic and protein material of cells during stressful conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuguang Lin et al.
Summary: The study found that AEFs extracted and purified from different animal species (camel, cat, cattle, goat, and mouse) could promote mouse SAA protein aggregation in vitro, with mouse and cat AEFs showing higher mSAA aggregation-promoting activity than camel, cattle, and goat AEFs. This suggests that AA amyloidosis exhibits higher transmission activity among animals carrying genetically homologous SAA gene, providing a new understanding of the pathogenesis of amyloidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olga V. Stepanenko et al.
Summary: Proteolytic enzymes can degrade amyloid fibrils, and the efficiency of degradation depends on the structure of the amyloid-forming protein and the morphology of amyloid fibrils. The relationship between amyloid structure and the efficiency of degradation may lead to a new method for analyzing amyloid polymorphism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Charuvaka Muvva et al.
Summary: The study utilized umbrella sampling simulations and electronic structure theory calculations to analyze the aggregation process of amyloid and tau protein sequences, revealing that monomers of these sequences exhibit alpha-helix like secondary structures, while dimers show double well potentials corresponding to alpha-helix and beta-sheet like secondary structures. Complementary semi-empirical and density functional theory calculations validated the force-field based free energy profiles obtained for these systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alexey P. Galkin et al.
Summary: Amyloidoses are a group of diseases characterized by the formation of pathological protein fibrils with cross-beta structures. Approximately 5-10% of cases are caused by amyloidogenic mutations or transmission of infectious amyloids, while sporadic amyloidoses are often associated with various underlying pathologies. The progression in treating vascular, metabolic, infectious diseases, and cancers can significantly reduce the risk of sporadic amyloidoses, which are believed to occur as a secondary event triggered by cellular stress response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alexander G. Bobylev et al.
Summary: The study found that amyloid aggregates of smooth-muscle titin can impair cell adhesion and lead to cell death. The surface roughness may be a key factor contributing to the highly antiadhesive properties. The negative impact of amyloid aggregates on cell adhesion is likely intrinsic to other amyloid proteins with similar structure and properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Tuomas P. J. Knowles et al.
ADVANCED MATERIALS
(2016)
