Ciliary Neurotrophic Factor (CNTF) and Its Receptors Signal Regulate Cementoblasts Apoptosis through a Mechanism of ERK1/2 and Caspases Signaling

Article Dentistry, Oral Surgery & Medicine

Influence of leptin and compression in GAS-6 mediated homeostasis of periodontal ligament cell

Jiawen Yong et al.

Summary: GAS-6 plays a promoting role in the homeostasis of periodontal ligament cells, and is associated with leptin and compressive forces. GAS-6 induces cell migration and proliferation, and regulates the expression of multiple genes.

ORAL DISEASES (2023)

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Article Biology

Selection and validation of reference gene for RT-qPCR studies in co-culture system of mouse cementoblasts and periodontal ligament cells

Jiawen Yong et al.

Summary: This study aimed to identify reliable reference genes suitable for RT-qPCR studies in a co-culture system of OCCM-30 and SV-PDL cells. The results showed that PPIB and POLR2A combination was the most stable reference gene combination in the co-culture system for normalizing gene expression in these two cell lines.

BMC RESEARCH NOTES (2022)

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Article Biochemistry & Molecular Biology

Immunorthodontics: Role of HIF-1α in the Regulation of (Peptidoglycan-Induced) PD-L1 Expression in Cementoblasts under Compressive Force

Jiawen Yong et al.

Summary: This in vitro study investigates the molecular mechanisms of PD-L1 expression in cementoblasts in response to infection with Porphyromonas gingivalis peptidoglycan and compressive force, and its interaction with hypoxia-inducible factor-1 alpha. The results suggest that PGN of P.gingivalis participates in PD-L1 upregulation in cementoblasts, and the influence of compressive force on this induction occurs in an HIF-1 alpha dependent manner.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

MAPK and beta-Catenin signaling: implication and interplay in orthodontic tooth movement

Jiawen Yong et al.

Summary: This article reviews the biology of orthodontic tooth movement and explores the interaction between MAPK and beta-Catenin signaling pathways in mechanosensory cells, providing potential strategies for further research and support for orthodontic interventions.

FRONTIERS IN BIOSCIENCE-LANDMARK (2022)

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Article Cell Biology

Adiponectin as Well as Compressive Forces Regulate in vitro β-Catenin Expression on Cementoblasts via Mitogen-Activated Protein Kinase Signaling Activation

Jiawen Yong et al.

Summary: The study revealed that adiponectin regulates the AdipoRs, MAPK, and beta-catenin signaling pathways in cementoblasts under compressive forces, promoting beta-catenin gene expression by activating P38 alpha, JNK1, ERK1, and ERK2. MAPK signaling plays a crucial role in regulating beta-catenin during cementogenesis. Moreover, adiponectin modulates GSK-3 beta and beta-catenin primarily through AdipoR1, with P38 alpha serving as a key connector between beta-catenin, TCF/LEF transcription, and MAPK signaling pathway.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Hypoxia-inducible factor 1-alpha acts as a bridge factor for crosstalk between ERK1/2 and caspases in hypoxia-induced apoptosis of cementoblasts

Jiawen Yong et al.

Summary: HIF-1 alpha and ERK1/2 play crucial roles in the apoptotic response of cementoblasts under hypoxic conditions. Adipokines such as resistin, visfatin, and ghrelin regulate different caspase gene expressions, providing potential targets for molecular intervention in obese patients undergoing orthodontic treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Cell Biology