期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms23158202
关键词
apoptotic bodies; apoptosis; intercellular communication; systemic diseases
资金
- National Nature Science Foundation of China [81991504, 81974149, 82122015]
- Innovation research team project of Beijing Stomatological Hospital, Capital Medical University [CXTD202202]
- Innovation Foundation of Beijing Stomatological Hospital, Capital Medical University [21-09-18]
- Beijing Stomatological Hospital, Capital Medical University Young Scientist Program [YSP202103]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX202121]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20181501]
- Beijing Municipal Administration of Hospitals' Youth Programme [QML20181501]
Apoptotic bodies (ApoBDs) generated from apoptotic cells play crucial roles in maintaining homeostasis, intercellular communications, and the treatment of systemic diseases. Research on the generation, application, and reconstruction of ApoBDs provides evidence and therapeutic strategies for understanding related diseases.
Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
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