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Immunology
Leila Mohamed Khosroshahi et al.
Summary: Immune checkpoint molecules prevent dangerous immune attacks by negative regulation of effector immune cells, each checkpoint reduces immunoactivation via distinct intracellular signaling mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
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Katarzyna Smolarczyk et al.
Summary: Sexually transmitted infections caused by Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium are common causes of pelvic inflammatory disease, which can lead to tubal factor infertility and adverse pregnancy outcomes. Antibiotic resistance in these pathogens is a significant problem, making treatment options and molecular approaches a key focus for researchers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Biochemistry & Molecular Biology
Karla Rio-Aige et al.
Summary: The study reveals that mothers pass natural passive immunity to their infants during gestation through the transplacental pathway, with differences in the plasma profile of immunoglobulins and cytokines between mothers and babies at birth. Additionally, maternal diet and microbiota composition have an impact on the levels and relationships of immune factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Article
Biochemistry & Molecular Biology
Heyam Hayder et al.
Summary: The overexpression of miR-210-3p reduces trophoblast migration and invasion, affects EVT outgrowth in early pregnancy explants, and decreases the ability of trophoblast to form endothelial-like networks. Furthermore, miR-210-3p downregulates the expression of certain cytokines, potentially influencing EVT invasion and immune cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kavita Narang et al.
Summary: Congenital and perinatal infections pose significant risks to pregnant women, potentially leading to fetal infection and long-term developmental consequences. Some pathogens can directly infect the fetus by crossing the placenta, while others induce maternal or placental inflammation that indirectly harms the fetus. The placenta is a temporary but critical organ that plays vital roles in facilitating fetal nutrition, oxygenation, and protection against in utero infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Romanowska-Prochnicka et al.
Summary: TNF-alpha plays a crucial role in influencing hormone synthesis, placental architecture, and embryonic development during pregnancy. Increased levels of TNF-alpha are associated with pregnancy loss and preeclampsia, and may also impact trophoblast biology and maternal immune cells. Additionally, the release of cytokines and chemokines in syncytiotrophoblasts may be affected by chronic inflammatory diseases in pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marta Magatti et al.
Summary: The pathophysiology of preeclampsia involves immune cells, with B cells playing a significant role in its development. Perinatal cells, derived from birth-associated tissues, have immunomodulatory properties that could potentially be used to regulate B cell activation and function, representing a novel therapeutic strategy for preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Biochemistry & Molecular Biology
Aneta Slabuszewska-Jozwiak et al.
Summary: The study found no significant differences in 5-mC/5-hmC ratio between intrapartum cesarean sections and vaginal deliveries. The ADIPOQ demethylation index was significantly higher in intrapartum cesarean sections compared to elective cesarean sections and vaginal deliveries. The demethylation index of LEP did not significantly differ among the three delivery groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Monika Baczkowska et al.
Summary: Placental abruption, a rare perinatal complication, involves the separation of the placenta from the uterus lining before childbirth, posing serious consequences and a high risk of maternal and fetal mortality. Disruption of immunological processes on the maternal-fetal interface plays a crucial role in the pathophysiology of this condition, requiring further research to fully understand this complex process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Iwona Bukowska-Osko et al.
Summary: This review focuses on the impact of COVID-19 on pregnant women, particularly on the mother-fetal-placenta interface in the potential transmission of SARS-CoV-2. It also discusses the antiviral activity of lactoferrin in pregnant women during viral infections and its role in potentially blocking/limiting the transmission of the virus to the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Malgorzata Gryka-Marton et al.
Summary: Neonatal lupus erythematosus is a syndrome of clinical symptoms observed in newborns born to mothers with antibodies, mainly anti-SS-A and anti-SS-B antibodies. These antibodies may trigger inflammatory reactions through the placenta, leading to symptoms in newborns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kirim Hong et al.
Summary: Preeclampsia is a complex hypertensive disorder in pregnancy that can be lethal and is considered one of the major risk factors for cardiovascular disease in women. In addition to the higher risk of unfavorable obstetric outcomes, the association between preeclampsia and postpartum cardiovascular health of the mother is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Biochemistry & Molecular Biology
Ananth Kumar Kammala et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Obstetrics & Gynecology
Danielle G. Tsevat et al.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)
Article
Immunology
Michael Pazos et al.
IMMUNOLOGIC RESEARCH
(2012)
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Multidisciplinary Sciences
Hariharan Subramanian et al.
Review
Immunology
Kam Lun Hon et al.
AUTOIMMUNE DISEASES
(2012)
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Obstetrics & Gynecology
Minna Tikkanen
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2011)
Review
Immunology
Leia C. R. Silva et al.
Review
Chemistry, Multidisciplinary
Xia Wang et al.
ACTA PHARMACOLOGICA SINICA
(2008)
Review
Infectious Diseases
PA Mårdh
CURRENT OPINION IN INFECTIOUS DISEASES
(2004)
