Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis

Article Cell Biology

Dynamic changes of exhaustion features in T cells during oral carcinogenesis

Wenqiang Xie et al.

Summary: T-cell dysfunction was established at the early premalignant phase of oral carcinogenesis; PD-1 blockade at the early premalignant phase can effectively reverse T-cell exhaustion features and then prevent carcinogenesis progression.

CELL PROLIFERATION (2022)

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Article Pathology

PD-1/PD-L1, Treg-related proteins, and tumour-infiltrating lymphocytes are associated with the development of oral squamous cell carcinoma

Omar Kujan et al.

Summary: This study aimed to evaluate the diagnostic utility of specific immunomodulator proteins and their role in the progression of oral squamous cell carcinoma (OSCC). The results showed that the PD-1/PD-L1 pathway, Treg-related proteins, and tumor infiltrating lymphocytes (TILs) were associated with the development of OSCC. Diagnostic models using these proteins and TILs accurately predicted the grade of oral epithelial disorder.

PATHOLOGY (2022)

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Review Multidisciplinary Sciences

Macrophage targeting in cancer

Martha Lopez-Yrigoyen et al.

Summary: Tumorigenesis is influenced by interactions between cancer cells and the tumor microenvironment. Tumor-associated macrophages play a crucial role in tumor development, with the potential to both promote antitumor responses and exhibit immunosuppressive protumor phenotypes. Targeting TAMs has become a strategy in cancer therapy, with a focus on reprogramming TAMs to support antitumor immune responses.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

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Review Oncology

The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer

Stephanie L. Goff et al.

Summary: The review highlights the presence and important roles of immune cells in both normal breast tissue and breast carcinoma, with an emphasis on the increased immune cell infiltrates during breast cancer progression. Different subtypes of immune cells within and around tumors present potential targets for immunotherapy strategies.

CLINICAL BREAST CANCER (2021)

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Review Biochemistry & Molecular Biology

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance

Fang Wei et al.

Summary: This review summarizes the metabolic reprogramming of various cell types in the tumor microenvironment, focusing on the interaction between the metabolic pathways of these cells and antitumor immunosuppression, as well as discussing potential new approaches to enhance antitumor immunotherapy through metabolic checkpoints.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Oncology

Microenvironmental modulation of the developing tumour: an immune-stromal dialogue

James O. Jones et al.

Summary: The successful establishment of a tumor relies on interactions between cancer cells and stromal cells in a evolving microenvironment, with key players transitioning from tumor elimination to promotion. While the tumor-stroma crosstalk in established tumors is well-studied, the early tumor microenvironment has received less attention due to challenges in studying this process in clinic or mouse models. Understanding the key factors in the early microenvironment may provide insights for clinical applications.

MOLECULAR ONCOLOGY (2021)

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Article Oncology

Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma

Jose A. Monteiro de Oliveira Novaes et al.

Summary: PD-1/PD-L1 pathway blockade and CD40 pathway activation were effective in preventing OPL progression into invasive OSCC in a murine model. Targeting of the CD40 and PD-1/PD-L1 pathways resulted in distinct patterns of immune modulation.

CANCER PREVENTION RESEARCH (2021)

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Review Otorhinolaryngology

Oral potentially malignant disorders: new insights for future treatment

Crisitna Gurizzan et al.

Summary: This review aims to define the issues regarding oral potentially malignant disorders (OPMDs) and provide an overview of treatments and ongoing clinical trials. Surgery is currently the preferred treatment for OPMD, but biomarkers identification is crucial in predicting malignant transformation. New prevention strategies and the concept of immune equilibrium may offer promising approaches for OPMD.

CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY (2021)

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Review Dentistry, Oral Surgery & Medicine

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer

Saman Warnakulasuriya et al.

Summary: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of oral cancer, and an expert group updated the nomenclature and classification of OPMDs, adding oral lichenoid lesions and oral manifestations of 'chronic graft-versus-host disease' to the list. It is recommended to establish a global research consortium to study the natural history of OPMDs based on the proposed classification.

ORAL DISEASES (2021)

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Review Immunology

Cancer Immunoprevention: Current Status and Future Directions

Mahsa Keshavarz-Fathi et al.

Summary: Cancer is a serious global health issue, with limited improvement in overall survival despite various treatment modalities. Immunoprevention has gained attention as a cancer prevention method, focusing on the identification of tumor antigens and design of preventive vaccines.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2021)

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Article Biochemistry & Molecular Biology

Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia

Jutta Ries et al.

Summary: Increased levels of PD-1 and PD-L1 are associated with malignant transformation in oral leukoplakia (OLP) and may serve as a promising prognostic indicator to determine the risk of malignant progression of OLP.

BIOMEDICINES (2021)

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Article Oncology

Immunotherapy for the prevention of high-risk oral disorders malignant transformation: the IMPEDE trial

Cristina Gurizzan et al.

Summary: OPMD have a significant risk of malignant transformation, with potential progression to oral cancer. This clinical trial aims to prevent neoplastic transformation of OPMD and revert LOH status by restoring immune system activity through immunotherapy. By using checkpoint inhibitors, the trial seeks to tip the balance in favor of immune control and prevent cancer occurrence.

BMC CANCER (2021)

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Article Oncology

Predicting the clinical outcome of oral potentially malignant disorders using transcriptomic-based molecular pathology

Hans Prakash Sathasivam et al.

Summary: This study developed and validated a gene expression signature to characterize oral potentially malignant disorders with a high risk of malignant transformation. The signature, composed of 11 genes, was able to predict patient risk scores in the test set and stratify the risk of malignant transformation, demonstrating promising clinical utility.

BRITISH JOURNAL OF CANCER (2021)

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Article Oncology

PD-1 blockade prevents the progression of oral carcinogenesis

Yunmei Dong et al.

Summary: T-cell exhaustion plays a crucial role in oral carcinogenesis, and PD-1 blockade can prevent the progression of oral cancer.

CARCINOGENESIS (2021)

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Review Cell Biology

Mechanoresponsive metabolism in cancer cell migration and metastasis

Matthew R. Zanotelli et al.

Summary: Altered tissue mechanics and metabolism are defining characteristics of cancer that impact both proliferation and migration. Changes in metabolism allow cells to dynamically adjust energy generation in response to fluctuating energy needs, while physical cues from the extracellular matrix influence mechanosignaling pathways affecting cell migration and metastasis. The role of mechanoresponsive metabolism in regulating cell migration and supporting metastasis is discussed, along with the potential of targeting cancer metabolism therapeutically to inhibit motility and potentially metastasis.

CELL METABOLISM (2021)

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Article Oncology

TNFα Signaling Is Increased in Progressing Oral Potentially Malignant Disorders and Regulates Malignant Transformation in an Oral Carcinogenesis Model

Jeffrey W. Chadwick et al.

Summary: Oral carcinogenesis is a multi-stage process involving genetic and molecular changes that promote the progression from OPMDs to OSCCs. TNFα and TNFR1 play important roles in this process, with increased expression observed in progressing OPMDs. Experimental models have shown upregulation of TNFα/TNFR1 expression in OSCCs, suggesting a potential role in malignant transformation.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Alteration of Macrophage Infiltrating Compartment: A Novel View on Oral Carcinogenesis

Manabu Shigeoka et al.

Summary: This review highlights the significance of macrophages in oral carcinogenesis and proposes studying the alteration of macrophage infiltrating compartments as a novel approach for gaining insights into cancer prevention and early detection.

PATHOBIOLOGY (2021)

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Review Virology

Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis

Luigi Santacroce et al.

Summary: This study focuses on the epidemiological characteristics and biomolecular mechanisms of HPV infections related to the development of precancerous and cancerous oral lesions. Evidence from literature suggests that HPV plays a role in potentially malignant oral disorders, contributing to benign lesions as well as oral carcinogenesis.

VIRUSES-BASEL (2021)

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Article Dentistry, Oral Surgery & Medicine

Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway

Jin Yang et al.

Summary: This study identified lncRNA H19 as a key regulator in oral cancer-associated fibroblasts (CAFs), with knockdown affecting proliferation, migration, and glycolysis. The lncRNA H19/miR-675-5p/PFKFB3 axis was found to be involved in promoting the glycolysis pathway in oral CAFs. The findings suggest a potential new biomarker for oral squamous cell carcinoma (OSCC) molecular diagnosis and a target for anti-tumor therapy.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2021)

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Review Dentistry, Oral Surgery & Medicine

Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis

Mohit Sharma et al.

Summary: This study elucidated the role of matrix stiffness in malignant transformation of oral submucous fibrosis, highlighting the involvement of YAP and TAZ in promoting cell migration, invasion, and epithelial-mesenchymal transition. It was found that increased matrix stiffness activates YAP and TAZ, serving as mechanical transducers to enhance tumor progression.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Oncology

Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model

Yewen Shi et al.

Summary: The research explores the use of immune checkpoint inhibitors to prevent the progression of oral premalignant lesions, showing that local delivery of PD-1 inhibitors can significantly reduce the advancement of OPL to carcinomas, providing evidence for the potential clinical value in treating oral cancer.

CANCER PREVENTION RESEARCH (2021)

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Review Oncology

Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment

Janice L. Farlow et al.

Summary: HNSCC, characterized by high tumor mutational burden, can evade immune recognition and suppress immune activation despite having a large neoantigen load. Research should focus on understanding how HNSCC tumors modulate their architecture, cellular composition, and cytokine milieu to maximize immunosuppression.

ORAL ONCOLOGY (2021)

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Article Oncology

Inhomogeneity of stiffness and density of the extracellular matrix within the leukoplakia of human oral mucosa as potential physicochemical factors leading to carcinogenesis

Katarzyna Pogoda et al.

Summary: Oral leukoplakia is a clinical term for precancerous lesions, with a lack of markers for cancer transformation. Studies found that leukoplakia samples had significantly higher stiffness than surrounding tissues, with heterogeneous stiffness likely promoting oncogenesis, while cancer samples had lower stiffness, potentially requiring tissue restructuring for a homogenous microenvironment.

TRANSLATIONAL ONCOLOGY (2021)

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Article Instruments & Instrumentation

Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies

Samira Aghlara-Fotovat et al.

Summary: This article highlights the importance of interactions between host immune cells and the extracellular matrix, discusses potential diseases caused by immune system dysregulation, and proposes therapeutic strategies to restore tissue balance.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Microbiology

Candida albicans and Oral Carcinogenesis. A Brief Review

Michele Di Cosola et al.

Summary: Current medical knowledge and research on patients' management, along with several protocols on minimizing risk of infection by Candida spp., are still evolving. The review in this work focuses on the epidemiological and biomolecular characteristics during Candida albicans infections, potential role of C. albicans in oral disorders and cancer, and the importance of oral flora in avoiding carcinogenesis.

JOURNAL OF FUNGI (2021)

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Article Oncology

Metabolomics study reveals the potential evidence of metabolic reprogramming towards the Warburg effect in precancerous lesions

Xun Chen et al.

Summary: The study found distinct metabolic characteristics in oral precancerous cells and cervical precancerous lesions compared to normal and cancer cells. Enhanced metabolic activity and increased expression of glycolytic enzymes were observed in cervical precancerous lesions, suggesting metabolic reprogramming may contribute to early tumorigenesis.

JOURNAL OF CANCER (2021)

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Article Oncology

Early changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of M2 macrophages with oral cancer free survival

Jebrane Bouaoud et al.

Summary: This study utilized RNA sequencing to investigate the dynamics of the immune microenvironment during oral carcinogenesis, highlighting the significant gene expression changes in the stromal compartment related to immune biological processes. The infiltration of macrophages was identified as the most quantitatively important, especially during the dysplasia stage. Additionally, three M2 macrophages signatures were found to be independently associated with improved oral cancer-free survival in patients with oral leukoplakia.

ONCOIMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Fanglong Wu et al.

Summary: CAFs play vital roles in cancer progression and their complex signaling pathways with cancer cells are crucial for understanding the development of cancer.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, General & Internal

Correlation of Mast Cell and Angiogenesis in Oral Lichen Planus, Dysplasia (Leukoplakia), and Oral Squamous Cell Carcinoma

Amutha Sundararajan et al.

Summary: This study aimed to compare and correlate mast cell density (MCD) and microvessel density (MVD) between normal oral mucosa, oral lichen planus, various grades of dysplasia, and oral squamous cell carcinoma (OSCC). The results indicated that both MCD and MVD were significantly increased in all lesions compared to normal oral mucosa, and showed a significant positive correlation overall.

RAMBAM MAIMONIDES MEDICAL JOURNAL (2021)

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Review Immunology

Fibroblasts as immune regulators in infection, inflammation and cancer

Sarah Davidson et al.

Summary: In different tissues and diseases, fibroblasts play a crucial role in regulating local immune responses by modulating inflammatory or immunosuppressive activities. Their diverse immunological properties highlight the importance of tissue context in determining fibroblast-immune cell interactions.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Which Factors Affect the Long-Term Survival of Patients With Oral Squamous Cell Carcinoma With Distant Metastasis?

Shoichi Sekikawa et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2020)

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Review Oncology

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu Lei et al.

CANCER LETTERS (2020)

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Review Allergy

Mast Cell Biology at Molecular Level: a Comprehensive Review

Daniel Elieh Ali Komi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Review Otorhinolaryngology

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype

Oreste Iocca et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2020)

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Article Immunology

Neutrophil extracellular traps (NETs) formation induced by TGF-β in oral lichen planus - Possible implications for the development of oral cancer

Ewa Jablonska et al.

IMMUNOBIOLOGY (2020)

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Article Cell Biology

Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression

Qiaozhen Yang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Dentistry, Oral Surgery & Medicine

Bibliometric analysis of the top-100 cited articles on oral potentially malignant disorders to guide research topic and direction

Liwei Ma et al.

JOURNAL OF DENTAL SCIENCES (2020)

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Article Dentistry, Oral Surgery & Medicine

A personalized computational model predicts cancer risk level of oral potentially malignant disorders and its web application for promotion of non-invasive screening

Xiangjian Wang et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2020)

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Article Multidisciplinary Sciences

Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma

Xin Pang et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

Adam P. Cribbs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Cell Biology

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Andrew M. K. Law et al.

CELLS (2020)

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Article Dentistry, Oral Surgery & Medicine

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment

L. Wen et al.

JOURNAL OF DENTAL RESEARCH (2020)

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Review Oncology

EMT Factors and Metabolic Pathways in Cancer

Ilias Georgakopoulos-Soares et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Oncology

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

Sylvie Brassart-Pasco et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Macrophage M1/M2 polarization

Chen Yunna et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Biochemical Research Methods

A pilot study for early detection of oral premalignant diseases using oral cytology and Raman micro-spectroscopy: Assessment of confounding factors

Isha Behl et al.

JOURNAL OF BIOPHOTONICS (2020)

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Article Multidisciplinary Sciences

Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: a pilot study

Kanan Dave et al.

SCIENTIFIC REPORTS (2020)

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Review Multidisciplinary Sciences

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Juliane Winkler et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression

Matthew Hadden et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Article Dentistry, Oral Surgery & Medicine

Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

Narges Gholizadeh et al.

BMC ORAL HEALTH (2020)

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Article Dentistry, Oral Surgery & Medicine

CD1a+and CD207+cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

Luan Cesar da Silva et al.

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL (2020)

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Review Oncology

Nerves in cancer

Ali H. Zahalka et al.

NATURE REVIEWS CANCER (2020)

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Article Dentistry, Oral Surgery & Medicine

FOXP3 lymphocyte status may predict the risk of malignant transformation in oral leukoplakia

Junki Sakata et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY (2020)

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Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Oncology

β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

Guanxi Qiao et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Dentistry, Oral Surgery & Medicine

Reduced CD8+ T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

Aline Lauda Freitas Chaves et al.

CLINICAL ORAL INVESTIGATIONS (2019)

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Review Cell Biology

Cancer associated fibroblasts: is the force the path to the dark side?

Jorge Barbazan et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

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Article Dentistry, Oral Surgery & Medicine

Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma

A. Kouketsu et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2019)

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Article Oncology

Glucose metabolism changes during the development and progression of oral tongue squamous cell carcinomas

Keiichiro Nakazato et al.

ONCOLOGY LETTERS (2019)

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Review Oncology

The Tumor Microenvironment Innately Modulates Cancer Progression

Dominique C. Hinshaw et al.

CANCER RESEARCH (2019)

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Article Medicine, Research & Experimental

Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction

Zahra Malekpour-Dehkordi et al.

LIFE SCIENCES (2019)

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Article Physiology

The Acidic Tumor Microenvironment as a Driver of Cancer

Ebbe Boedtkjer et al.

Annual Review of Physiology (2019)

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Review Oncology

Cytokines in clinical cancer immunotherapy

Pedro Berraondo et al.

BRITISH JOURNAL OF CANCER (2019)

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Article Oncology

Role of stromal myofibroblasts in the progression of oral lesions from dysplasia to invasive carcinoma

Aeman Khalid et al.

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY (2019)

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Review Oncology

Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders

Gargi S. Sarode et al.

ONCOLOGY REVIEWS (2019)

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Article Dentistry, Oral Surgery & Medicine

CD163+ macrophages infiltration correlates with the immunosuppressive cytokine interleukin 10 expression in tongue leukoplakia

Manabu Shigeoka et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2019)

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Article Immunology

Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties

Carolyn G. J. Moonen et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Physiology

Roles of pH in control of cell proliferation

M. Flinck et al.

ACTA PHYSIOLOGICA (2018)

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Review Chemistry, Multidisciplinary

Mechanobiology of Tumor Growth

Parthiv Kant Chaudhuri et al.

CHEMICAL REVIEWS (2018)

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Article Biochemistry & Molecular Biology

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene-induced senescence

Giulia Santinon et al.

EMBO JOURNAL (2018)

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Article Dentistry, Oral Surgery & Medicine

Role of tissue-specific steroid metabolism in oral disease: Is there any clinical implication?

N. Cirillo

ORAL DISEASES (2018)

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Review Oncology

The impact of tumor cell metabolism on T cell-mediated immune responses and immuno-metabolic biomarkers in cancer

Gregory Noel et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Article Cell Biology

Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1 alpha signaling pathway

Jie Wei et al.

CELL DEATH & DISEASE (2018)

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Article Immunology

CD8+and CD163+infiltrating cells and PD-L1 immunoexpression in oral leukoplakia and oral carcinoma

Olga Stasikowska-Kanicka et al.

APMIS (2018)

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Review Biochemistry & Molecular Biology

Immune checkpoint inhibitors: recent progress and potential biomarkers

Pramod Darvin et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Review Cell Biology

Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression

James B. McCarthy et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

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Article Immunology

Liver-infiltrating CD11b(-)CD27(-) NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression

Qiong-Fang Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

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Review Dentistry, Oral Surgery & Medicine

The role of hypoxia in oral cancer and potentially malignant disorders: a review

Omar Kujan et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2017)

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Article Oncology

Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions

Takahiro Yagyuu et al.

ORAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

Ali H. Zahalka et al.

SCIENCE (2017)

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Review Oncology

Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy

Ruixue Ai et al.

ONCOTARGET (2017)

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Article Cell Biology

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Daniel Hargbol Madsen et al.

CELL REPORTS (2017)

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Editorial Material Immunology

Neutrophils: Their Role in Innate and Adaptive Immunity 2017

Carlos Rosales et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2017)

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Article Pharmacology & Pharmacy

The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO

Giada Mondanelli et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

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Article Oncology

PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions

Jin Wang et al.

CANCER PREVENTION RESEARCH (2017)

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Article Dentistry, Oral Surgery & Medicine

Difference in glycogen metabolism (glycogen synthesis and glycolysis) between normal and dysplastic/malignant oral epithelium

Hitoshi Aizawa et al.

ARCHIVES OF ORAL BIOLOGY (2017)

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Article Medicine, General & Internal

Histomorphometric Analysis of Angiogenesis using CD31 Immunomarker and Mast Cell Density in Oral Premalignant and Malignant Lesions: A Pilot Study

M. Jyothsna et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2017)

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Review Oncology

Redirecting the focus of cancer immunotherapy to premalignant conditions

M. Rita I. Young

CANCER LETTERS (2017)

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Article Biochemistry & Molecular Biology

Monocarboxylate transporters in the brain and in cancer

Jhudit Perez-Escuredo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Article Medicine, Research & Experimental

Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer

Preety Ghanghas et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Medicine, Research & Experimental

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Thomas Bertero et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Dentistry, Oral Surgery & Medicine

Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States

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