4.7 Review

Current Knowledge in Skin Metabolomics: Updates from Literature Review

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Review Dermatology

A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors

Viktor Masutin et al.

Summary: This study reviewed the current literature and analyzed the metabolic changes in the skin. The results showed that energy metabolism, lipid metabolism, antioxidant defense, and DNA repair systems were most affected by the investigated factors.

EXPERIMENTAL DERMATOLOGY (2022)

Article Biochemical Research Methods

Untargeted 2D NMR Metabolomics of [13C-methyl]Methionine-Labeled Tumor Models Reveals the Non-DNA Methylome and Provides Clues to Methyl Metabolism Shift during Tumor Progression

Daniel Morvan et al.

Summary: Nutrient availability influences epigenetic methylations, and different tumor models may exhibit distinct global methylomes at different stages of development, providing clues to shifts in methyl metabolism during tumor progression.

JOURNAL OF PROTEOME RESEARCH (2022)

Article Dermatology

Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome

Hila Emmert et al.

Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.

EXPERIMENTAL DERMATOLOGY (2021)

Article Oncology

Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma

Jose Luis Palacios-Ferrer et al.

Summary: Malignant melanoma, the most aggressive form of skin cancer, is characterized by its extraordinary metastasis capacity and chemotherapy resistance, mainly due to melanoma cancer stem cells. Current clinical biomarkers for this neoplasia are lacking, highlighting the urgent need for new biomarkers to enable early diagnosis and effective disease monitoring. Exosomes, a novel source of biomarkers, show significant metabolomic differences in MM CSC-derived exosomes and serum-derived exosomes from patients with MM compared to healthy controls, indicating their potential as clinically useful biomarkers for MM diagnosis.

MOLECULAR ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation

Paul Schilf et al.

Summary: The study demonstrates that natural variations in mtDNA can influence cellular metabolism and disease susceptibility in inflammatory skin conditions, providing experimental evidence for the relationship between mitochondria and chronic inflammatory conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Critical Care Medicine

Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model

Abdulnaser Alkhalil et al.

Summary: The study used a murine burn injury model to explore changes in the metabolome following thermal injury. The serum metabolome showed a quicker response to burn injury compared to the skin, while the metabolic response in the skin was less synchronous.

JOURNAL OF BURN CARE & RESEARCH (2021)

Article Physiology

Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect

Johannes Wild et al.

Summary: Psoriatic animals lose large amounts of water due to defective skin barrier, leading to metabolic adaptive water conservation responses including mobilization of nitrogen and energy from muscle, solute-driven anti-diuresis, and cutaneous vasoconstriction. Heat exposure results in blood pressure normalization but exacerbates transepidermal water loss.

ACTA PHYSIOLOGICA (2021)

Article Dermatology

Measurement of Melanin Metabolism in Live Cells by [U-13C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry

Qiuying Chen et al.

Summary: A new method was developed to actively measure the synthesis of both eumelanin and pheomelanin using liquid chromatography-mass spectrometry, shedding new light on melanin synthesis and revealing new insights into the mechanisms of melanogenesis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Dermatology

Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming

Soumitra Marathe et al.

Summary: IL-9 plays a critical role in metabolic reprogramming and survival of human primary keratinocytes by disrupting the electron transport chain, reducing tricarboxylic acid cycle intermediates, promoting glucose consumption, and inhibiting apoptosis.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Chemistry, Analytical

UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics

Tingting Li et al.

Summary: This study investigated the metabolic network of HaCaT cells after exposure to withanolides and demonstrated the inhibitory effect on cell proliferation, induction of cell apoptosis, and generation of reactive oxygen species and mitochondrial depolarization in HaCaT cells. By utilizing UPLC-orbitrap-MS, significant variations in 38 differential metabolites were identified between withanolides exposure and untreated groups, revealing disturbances in energy metabolism, amino acid metabolism, lipid metabolism, and nucleic acid metabolism. The study provides insights into potential therapeutic targets for treating psoriasis.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Article Environmental Sciences

New insights into the cellular mechanism of triclosan-induced dermal toxicity from a combined metabolomic and lipidomic approach

Yanshan Liang et al.

Summary: The study found that exposure to TCS led to elevation of purine and glutathione metabolism, down-regulation of amino acid metabolism, and dysregulation of lipid metabolism in human HaCaT keratinocytes. As a result, overproduction of reactive oxygen species and accumulation of ammonia occurred, contributing to oxidative stress and inflammation related to cell apoptosis.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Endocrinology & Metabolism

Skin Metabolomics

Decibel P. Elpa et al.

Summary: The skin retains a variety of metabolites that play important physiological roles and can be detected to diagnose and treat diseases. Miniature probes have been developed to detect high-abundance metabolites secreted with sweat, and analysis methods such as chromatography and mass spectrometry are used to study a broad spectrum of skin metabolites.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

Article Multidisciplinary Sciences

The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis

Yujin Lee et al.

Summary: Exposure to propyl-paraben is associated with aeroallergen sensitization and EASI score, but not with AD. Metabolic perturbations induced by propyl-paraben are related to serine and glycine metabolisms, branched-chain amino acid metabolism, and ammonia recycling.

SCIENTIFIC REPORTS (2021)

Article Oncology

Metabolomic Analysis of Actinic Keratosis and SCC Suggests a Grade-Independent Model of Squamous Cancerization

Valeria Righi et al.

Summary: The study assessed the metabolomic fingerprints of AK I, AK II, AK III and SCC, finding that AK I are metabolically active lesions with profiles similar to high-grade AKs and SCC. The negative association of AKs with parakeratosis and positive association with hypertrophy suggest a similar behavior between AKs and SCCs. The findings support the notion that all AKs should be treated independently, as they may be associated with SCC.

CANCERS (2021)

Article Dermatology

Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes

Toshihiro Kishikawa et al.

Summary: This study conducted metabolome analysis to identify metabolite biomarkers of psoriasis and its subtypes PsA and PsC, revealing significant changes in specific metabolites and differences between PsA and PsC, contributing to the understanding of psoriasis pathophysiology.

JOURNAL OF DERMATOLOGICAL SCIENCE (2021)

Article Health Care Sciences & Services

Multiscale Biology of Cardiovascular Risk in Psoriasis: Protocol for a Case-Control Study

Hannah Kaiser et al.

Summary: This study aims to characterize the complexity of cardiovascular risk in patients with psoriasis by integrating deep phenotypic data with systems biology techniques. Preliminary findings suggest that vascular inflammation in certain areas was reduced in patients treated with statins, highlighting the potential impact of novel insights gained through this systems biology approach.

JMIR RESEARCH PROTOCOLS (2021)

Article Multidisciplinary Sciences

Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis

Elisabetta Tarentini et al.

Summary: The study analyzed the metabolic and cytokine profiles in patients with psoriasis, revealing significant changes in ascorbate and scyllo-inositol levels in psoriatic skin. There was a notable increase in dimethylglycine and isoleucine in serum, and elevated levels of early inflammatory cytokines in psoriatic skin. Integration of metabolic and immune data identified specific cytokines and metabolites that could potentially serve as diagnostic markers for new-onset psoriasis.

SCIENTIFIC REPORTS (2021)

Article Toxicology

Safety assessment of cosmetics by read across applied to metabolomics data of in vitro skin and liver models

Carine Jacques et al.

Summary: This study used metabolomics and read across methods to compare the cosmetic ingredient DIV665 with the reference compound PA102, demonstrating biological similarity in skin and liver metabolism. The findings suggest that DIV665, when applied according to consumer topical use scenario, is likely to exhibit low local skin and systemic toxicity similar to PA102.

ARCHIVES OF TOXICOLOGY (2021)

Article Materials Science, Multidisciplinary

Integrated Microscopy and Metabolomics to Test an Innovative Fluid Dynamic System for Skin Explants In Vitro

Enrica Cappellozza et al.

Summary: In vitro models are important for the development of transcutaneous drugs, but synthetic membranes or cell cultures cannot fully mimic the properties of the cutaneous barrier. Maintaining explanted skin samples in a fluid dynamic environment significantly improves the preservation of their structural and functional characteristics, providing a reliable system for testing novel therapeutic agents.

MICROSCOPY AND MICROANALYSIS (2021)

Article Multidisciplinary Sciences

Metabolomics study of fibroblasts damaged by UVB and BaP

Xiaoyu Yang et al.

Summary: By studying the metabolic changes in human foreskin fibroblast cells injured by UVB, BaP, or the combination of the two, it was found that multiple main metabolites such as glycerophosphocholine and glutathione are related to the metabolic mechanisms involved. This provides valuable insights into the underlying mechanisms of UVB and BaP damage to skin cells.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Multi-omics analysis to decipher the molecular link between chronic exposure to pollution and human skin dysfunction

Namita Misra et al.

Summary: Environmental pollution can worsen skin disorders such as eczema, acne, lentigines, and wrinkles, with pollutants interacting with the skin surface and potentially contaminating deep skin tissues. The molecular mechanisms behind skin dysfunction due to pollution exposure are not well understood in humans. Skin microbiome is also affected by environmental aggressors and can contribute to visible clinical manifestations like wrinkles and aging.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention

Zhaoming Zhu et al.

Summary: The combined label-free proteomic and metabolomic methods were utilized to investigate the mechanisms of Cryptotanshinone intervention in acne rats. Significant alterations in skin metabolites and proteins were observed, contributing to the understanding of CPT's effectiveness in treating acne. The results suggest that CPT can regulate key metabolic pathways, immune responses, and inflammatory processes involved in acne pathogenesis, making it a promising candidate for acne treatment.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Pithecellobium clypearia: Amelioration Effect on Imiquimod-Induced Psoriasis in Mice Based on a Tissue Metabonomic Analysis

Ying Li et al.

Summary: The ethanol fraction of water extract (ESW) from Pithecellobium clypearia has shown significant therapeutic effects against psoriasis-like skin inflammation induced by IMQ in mice, mainly composed of gallic acid and quercetin. Metabolomics study revealed that ESW regulates multiple metabolic pathways to achieve its antipsoriasis effects.

FRONTIERS IN PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production

Parmanand Malvi et al.

Summary: ASAH1 is overexpressed in melanoma cells and promotes tumor growth and metastasis by suppressing peroxisome biogenesis and inhibiting ROS production. Targeting ASAH1 can inhibit melanoma growth and enhance the effectiveness of BRAF kinase inhibitors.

MOLECULAR METABOLISM (2021)

Article Biochemistry & Molecular Biology

Enhanced Access to the Health-Related Skin Metabolome by Fast, Reproducible and Non-Invasive WET PREP Sampling

Jamie Afghani et al.

Summary: Skin metabolomics plays a critical role in understanding physical and mental health, with the skin metabolome sampling technique of WET PREP offering a promising and non-invasive approach. Compared to swab collection, WET PREP provides a more stable shared metabolome across individuals and captures unique individual metabolites with high consistency in intra-individual reproducibility. The quick preparation time, low cost, and gentleness for the patient make WET PREP a preferred skin metabolome sampling technique for clinical studies.

METABOLITES (2021)

Article Dermatology

Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress

Liis Ilves et al.

Summary: This study aimed to characterize the metabolomic profile of lesional skin of patients with atopic dermatitis, and found significant differences in 77 metabolites and their ratios between lesional skin of atopic dermatitis, non-lesional skin of atopic dermatitis, and skin of controls. The alterations in metabolite levels suggest inflammation, impaired barrier function, and susceptibility to oxidative stress in atopic skin.

ACTA DERMATO-VENEREOLOGICA (2021)

Article Medicine, Research & Experimental

Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis

Chao Chen et al.

Summary: The study revealed significant alterations in the metabolism of amino acids and carnitines in patients with psoriasis. Particularly, the metabolism of essential amino acids, branched-chain amino acids, and L-carnitine may play key roles in the pathogenesis of psoriasis.

THERANOSTICS (2021)

Article Cell Biology

Delineating cell behavior and metabolism of non-melanoma skin cancer in vitro

Tatiana Mendez et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2020)

Article Biochemical Research Methods

Host Metabolic Response in Early Lyme Disease

Bryna L. Fitzgerald et al.

JOURNAL OF PROTEOME RESEARCH (2020)

Article Biochemistry & Molecular Biology

Human Melanoma-Cell Metabolic Profiling: Identification of Novel Biomarkers Indicating Metastasis

Mariangela Kosmopoulou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemical Research Methods

Chemical profiling of the human skin surface for malaria vector control via a non-invasive sorptive sampler with GCxGC-TOFMS

Madelien Wooding et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment

Nicholas J. Taylor et al.

PLOS ONE (2020)

Article Biochemistry & Molecular Biology

Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data

Ali Khosravi et al.

MOLECULAR MEDICINE (2019)

Review Physiology

METABOLOMICS FOR INVESTIGATING PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL PROCESSES

David S. Wishart

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Metabolomics Distinguishes DOCK8 Deficiency from Atopic Dermatitis: Towards a Biomarker Discovery

Minnie Jacob et al.

METABOLITES (2019)

Article Biochemical Research Methods

UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways

Annapoorna Sreedhar et al.

PROTEOMICS (2019)

Article Biochemical Research Methods

3D molecular cartography using LC-MS facilitated by Optimus and 'ili software

Ivan Protsyuk et al.

NATURE PROTOCOLS (2018)

Article Chemistry, Analytical

Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics

Megan M. Niedzwiecki et al.

ANALYTICAL CHEMISTRY (2018)

Article Dermatology

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair

Jason Hellmann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Chemistry, Multidisciplinary

Differential effects of graphene materials on the metabolism and function of human skin cells

Javier Frontinan-Rubio et al.

NANOSCALE (2018)

Article Multidisciplinary Sciences

Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans

Consuelo M. De Moraes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Cell Biology

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation

Mohsen Hosseini et al.

CELL REPORTS (2018)

Article Biochemical Research Methods

Cross-platform metabolomics investigating the intracellular metabolic alterations of HaCaT cells exposed to phenanthrene

Guoting Jiang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)

Article Dermatology

MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo

Anupama Sahoo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Article Dermatology

Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation

Mrinal K. Sarkar et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Article Cell Biology

Metabolic differentiation of early Lyme disease from southern tick-associated rash illness ( STARI)

Claudia R. Molins et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Multidisciplinary Sciences

NMR metabolic fingerprints of murine melanocyte and melanoma cell lines: application to biomarker discovery

Arquimedes Paixao de Santana-Filho et al.

SCIENTIFIC REPORTS (2017)

Article Medical Laboratory Technology

Hydrogel Micropatch and Mass Spectrometry-Assisted Screening for Psoriasis-Related Skin Metabolites

Ewelina P. Dutkiewicz et al.

CLINICAL CHEMISTRY (2016)

Article Allergy

Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study

Aukse Zinkevitiene et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)

Article Infectious Diseases

Exploratory urinary metabolomics of type 1 leprosy reactions

Oleg. A. Mayboroda et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2016)

Article Biochemical Research Methods

Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile

Mie R. Rasmussen et al.

JOURNAL OF PROTEOME RESEARCH (2016)

Review Endocrinology & Metabolism

Understanding Metabolomics in Biomedical Research

Su Jung Kim et al.

ENDOCRINOLOGY AND METABOLISM (2016)

Article Biochemical Research Methods

Human sweat metabolomics for lung cancer screening

Monica Calderon-Santiago et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells

Katherine A. Hollywood et al.

MOLECULAR BIOSYSTEMS (2015)

Article Pharmacology & Pharmacy

Data integration reveals key homeostatic mechanisms following low dose radiation exposure

Susan C. Tilton et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

Article Cell Biology

Targeted metabolic profiling of wounds in diabetic and nondiabetic mice

Ravi F. Sood et al.

WOUND REPAIR AND REGENERATION (2015)

Article Multidisciplinary Sciences

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease

Fatoumata Niang et al.

SCIENTIFIC REPORTS (2015)

Article Biochemistry & Molecular Biology

1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity

Purnima Khandelwal et al.

JOURNAL OF LIPID RESEARCH (2014)

Article Multidisciplinary Sciences

Knowledge discovery by accuracy maximization

Stefano Cacciatore et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, Research & Experimental

Prognostic relationship of metabolic profile obtained of melanoma B16F10

Thiago Antonio Fedele et al.

BIOMEDICINE & PHARMACOTHERAPY (2013)

Article Multidisciplinary Sciences

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

Robert S. Jansen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Dermatology

Metabolic changes in psoriatic skin under topical corticosteroid treatment

Beathe Sitter et al.

BMC DERMATOLOGY (2013)

Review Chemistry, Analytical

Modern analytical techniques in metabolomics analysis

Aihua Zhang et al.

ANALYST (2012)

Article Biochemical Research Methods

Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy

Richard P. Horgan et al.

JOURNAL OF PROTEOME RESEARCH (2011)

Article Cell Biology

Metabolomics

Jeffrey R. Idle et al.

CELL METABOLISM (2007)

Review Biochemistry & Molecular Biology

Metabolomics - the link between genotypes and phenotypes

O Fiehn

PLANT MOLECULAR BIOLOGY (2002)