4.7 Review

New Insights into TRP Ion Channels in Stem Cells

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出版社

MDPI
DOI: 10.3390/ijms23147766

关键词

TRPs; stemness; self-renewal; proliferation; cell cycle; calcium influx

资金

  1. scientific research fund of the educational department of Liaoning Province [LZ2020019]

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This review summarizes the expressions and functions of TRP ion channels in stem cells, including cancer stem cells, highlighting their role in sensory functions and regulation of stem cell characteristics.
Transient receptor potential (TRP) ion channels are cationic permeable proteins located on the plasma membrane. TRPs are cellular sensors for perceiving diverse physical and/or chemical stimuli; thus, serving various critical physiological functions, including chemo-sensation, hearing, homeostasis, mechano-sensation, pain, taste, thermoregulation, vision, and even carcinogenesis. Dysregulated TRPs are found to be linked to many human hereditary diseases. Recent studies indicate that TRP ion channels are not only involved in sensory functions but are also implicated in regulating the biological characteristics of stem cells. In the present review, we summarize the expressions and functions of TRP ion channels in stem cells, including cancer stem cells. It offers an overview of the current understanding of TRP ion channels in stem cells.

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