Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies

As the global aging process continues to lengthen, aging-related diseases (e.g., chronic obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly population. Aging is a complex biological process involving multiple tissues and organs and is involved in the development and progression of multiple aging-related diseases. At the same time, some of these aging-related diseases are often accompanied by hypoxia, chronic inflammation, oxidative stress, and the increased secretion of the senescence-associated secretory phenotype (SASP). Hypoxia seems to play an important role in the process of inflammation and aging, but is often neglected in advanced clinical research studies. Therefore, we have attempted to elucidate the role played by different degrees and types of hypoxia in aging and aging-related diseases and their possible pathways, and propose rational treatment options based on such mechanisms for reference.

Automated summary

As the global aging process continues, aging-related diseases are becoming more prevalent among the elderly population. These diseases are influenced by various factors including aging itself, hypoxia, chronic inflammation, and oxidative stress. However, the role of hypoxia in inflammation and aging is often overlooked in advanced clinical research. Therefore, our study aims to investigate the specific effects of hypoxia in aging and aging-related diseases, as well as potential treatment options.