期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms23147837
关键词
platelet-derived extracellular vesicles; thrombosis; immune mediated
资金
- Office of Research and Development and Department of Veterans Affairs [I01CX001932]
- National Institutes of Health [T32 HL007344]
This review article provides information on the important roles of platelet-derived extracellular vesicles (PEVs) in hemostasis and thrombosis, including their production mechanisms, characteristics, cellular interactions, and pathological role in diseases. The article also highlights the mechanisms through which PEVs can activate parent cells in a feedback loop.
Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据