☆ 4.7 Editorial Material

Editorial to the Special Issue Activations of Cadherin Signaling in Cancer

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19

Ikram Omar Osman et al.

Summary: COVID-19 is the largest pandemic in this century, and it is not only characterized by respiratory damage, but also by gastrointestinal symptoms. This study suggests that SARS-CoV-2 may cause damage to the epithelial barrier of the intestines by disrupting E-cadherin adherens junctions, leading to gastrointestinal symptoms.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Otorhinolaryngology

p120 regulates E-cadherin expression in nasal epithelial cells in chronic rhinosinusitis

Xue-Li Li et al.

Summary: This study found that p120 is involved in regulating the expression of E-cadherin protein in chronic rhinosinusitis. Inflammatory mediators reduce the expression of E-cadherin and p120 and increase paracellular permeability. Dexamethasone can alleviate the reduction of E-cadherin and p120 caused by inflammatory mediators.

RHINOLOGY (2022)

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Editorial Material Oncology

E-Cadherin: Context-Dependent Functions of a Quintessential Epithelial Marker in Metastasis

Cao Fang et al.

Summary: Loss of E-cadherin is not only linked to cancer metastasis, but also influences cell signaling events and cellular plasticity. This study highlighted the importance of E-cadherin as a global regulator in driving EMT and the metastatic phenotype, inspiring further research in the field.

CANCER RESEARCH (2021)

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Article Cell Biology

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling

Xinya Gao et al.

Summary: The activation of EGFR signalling in GBM is driven by a newly discovered secretory E-cadherin protein variant called C-E-Cad encoded by circular RNA. This mechanism promotes tumorigenicity in glioma stem cells and provides a promising approach for treating EGFR-driven GBM by enhancing the efficacy of anti-EGFR strategies.

NATURE CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

The functional activity of E-cadherin controls tumor cell metastasis at multiple steps

Tae-Young Na et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Biochemistry & Molecular Biology

Role of Cadherins in Cancer-A Review

Ilona Kaszak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

Amanda C. Daulagala et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis

J. Ignacio Casal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Structure-Based Virtual Screening Allows the Identification of Efficient Modulators of E-Cadherin-Mediated Cell-Cell Adhesion

Andrea Dalle Vedove et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Tumor-Derived Exosomes Mediate the Instability of Cadherins and Promote Tumor Progression

Bowen Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

E-cadherin Downregulation and microRNAs in Sporadic Intestinal-Type Gastric Cancer

Tania Rossi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells

Davide Ceresa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins

Chiara Battistini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

Katia Rea et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

Maggie K. S. Tang et al.

NATURE COMMUNICATIONS (2018)

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Review Oncology

Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer

Qi-Ping Hu et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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Article Chemistry, Medicinal

Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction

Valentina Nardone et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Editorial Material Multidisciplinary Sciences

A collective route to metastasis: Seeding by tumor cell clusters

Kevin J. Cheung et al.

SCIENCE (2016)

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Article Oncology

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

Tamer T. Onder et al.

CANCER RESEARCH (2008)

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